FeCH Ferrochelatase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: FeCHprovided by FlyBase
Official Full Name: Ferrochelataseprovided by FlyBase
Primary source: FLYBASE:FBgn0266268
Locus tag: Dmel_CG2098
See related: AllianceGenome:FB:FBgn0266268
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG2098; Dmel\CG2098; ferrochelatase
Summary: Enables ferrochelatase activity. Predicted to be involved in heme biosynthetic process. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrion. Is expressed in several structures, including adult head; adult heart; dorsal pharyngeal muscle cell; embryonic/larval midgut primordium; and gut section. Human ortholog(s) of this gene implicated in cutaneous porphyria and erythropoietic protoporphyria. Orthologous to human FECH (ferrochelatase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 100D2-100D2; 3-102 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (31810460..31812296, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (27636182..27638018, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ferrochelatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ferrochelatase activity	IDA Inferred from Direct Assay more info	PubMed
enables ferrochelatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in heme biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in heme biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in heme biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: ferrochelatase

Names: CG2098-PA; CG2098-PB; CG2098-PC; FeCH-PA; FeCH-PB; FeCH-PC

NP_524613.1

EC 4.98.1.1

NP_733458.1

EC 4.98.1.1

NP_733459.2

EC 4.98.1.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

31810460..31812296 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079874.3 → NP_524613.1 ferrochelatase, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524613.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O76533, Q8IGA4, Q8IH67, Q8IMF9, Q95U82, Q9V9S8

Related

FBpp0085208

Conserved Domains (3) summary

cd00419
Location:195 → 332

Ferrochelatase_C; Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is ...

cd03411
Location:29 → 190

Ferrochelatase_N; Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is ...

pfam00762
Location:29 → 349

Ferrochelatase; Ferrochelatase
NM_170579.3 → NP_733458.1 ferrochelatase, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_733458.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9V9S8

Related

FBpp0085209

Conserved Domains (3) summary

cd00419
Location:195 → 280

Ferrochelatase_C; Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is ...

cd03411
Location:29 → 190

Ferrochelatase_N; Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is ...

pfam00762
Location:29 → 280

Ferrochelatase; Ferrochelatase
NM_170580.3 → NP_733459.2 ferrochelatase, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_733459.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9V9S8

Related

FBpp0085210

Conserved Domains (2) summary

cd00419
Location:37 → 174

Ferrochelatase_C; Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is ...

pfam00762
Location:21 → 191

Ferrochelatase; Ferrochelatase