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    obst-E obstructor-E [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33806, updated on 9-Dec-2024

    Summary

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    Official Symbol
    obst-Eprovided by FlyBase
    Official Full Name
    obstructor-Eprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031737
    Locus tag
    Dmel_CG11142
    See related
    AllianceGenome:FB:FBgn0031737
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11142; Dmel\CG11142; Obst-E
    Summary
    Enables chitin binding activity. A structural constituent of chitin-based larval cuticle and structural constituent of pupal chitin-based cuticle. Involved in chitin-based cuticle development. Located in chitin-based extracellular matrix. Is expressed in adult brain cell body rind and cuticle. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See obst-E in Genome Data Viewer
    Location:
    25F4-25F4; 2-17 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (5762553..5766142, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (5762553..5766142, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR31912 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mechanical Control of Whole Body Shape by a Single Cuticular Protein Obstructor-E in Drosophila melanogaster. Tajiri R, et al. PLoS Genet, 2017 Jan. PMID 28076349, Free PMC Article
    2. Notch signaling generates the "cut here line" on the cuticle of the puparium in Drosophila melanogaster. Tajiri R, et al. iScience, 2023 Aug 18. PMID 37529108, Free PMC Article
    3. Tweedle proteins form extracellular two-dimensional structures defining body and cell shape in Drosophila melanogaster. Zuber R, et al. Open Biol, 2020 Dec. PMID 33292106, Free PMC Article
    4. Identification of the novel evolutionary conserved obstructor multigene family in invertebrates. Behr M, et al. FEBS Lett, 2005 Dec 19. PMID 16325182
    5. Reduction in maternal Polycomb levels contributes to transgenerational inheritance of a response to toxic stress in flies. Stern S, et al. J Physiol, 2014 Jun 1. PMID 24535443, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Obst-E regulates the arrangement of chitin and directs the formation of supracellular ridges on the larval cuticle.
      Title: Mechanical Control of Whole Body Shape by a Single Cuticular Protein Obstructor-E in Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chitin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chitin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of chitin-based larval cuticle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of pupal chitin-based cuticle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chitin-based cuticle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chitin-based extracellular matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    obstructor-E
    Names
    CG11142-PA
    CG11142-PB
    obst-E-PA
    obst-E-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      5762553..5766142 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_164659.3 → NP_723116.1  obstructor-E, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723116.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8IGU3, Q8T0V6, Q9VMM6
      Related
      FBpp0078795
      Conserved Domains (2) summary
      smart00494
      Location:23 → 65
      ChtBD2; Chitin-binding domain type 2
      pfam01607
      Location:180 → 225
      CBM_14; Chitin binding Peritrophin-A domain

    2. NM_135113.3 → NP_608957.1  obstructor-E, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608957.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VMM6
      Related
      FBpp0078794
      Conserved Domains (1) summary
      pfam01607
      Location:103 → 147
      CBM_14; Chitin binding Peritrophin-A domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VMM6.2 Q9VMM6

    Gene LinkOut

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