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    obe obelus [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41891, updated on 9-Dec-2024

    Summary

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    Official Symbol
    obeprovided by FlyBase
    Official Full Name
    obelusprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038344
    Locus tag
    Dmel_CG5205
    See related
    AllianceGenome:FB:FBgn0038344
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg5205; CG5205; Dmel\CG5205
    Summary
    Predicted to enable 3'-5' DNA helicase activity. Involved in regulation of alternative mRNA splicing, via spliceosome. Predicted to be part of U5 snRNP. Predicted to be active in nucleus. Is expressed in adult head; organism; and spermatozoon. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder. Orthologous to human ASCC3 (activating signal cointegrator 1 complex subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See obe in Genome Data Viewer
    Location:
    88F6-88F6; 3-57 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15486050..15493310)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11311772..11319032)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Rhodopsin 6 Neighboring gene trissin Neighboring gene maca Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Ski2-family helicase Obelus regulates Crumbs alternative splicing and cell polarity. Vichas A, et al. J Cell Biol, 2015 Dec 7. PMID 26644515, Free PMC Article
    2. Drosophila Syncrip binds the gurken mRNA localisation signal and regulates localised transcripts during axis specification. McDermott SM, et al. Biol Open, 2012 May 15. PMID 23213441, Free PMC Article
    3. Nonsense-mediated mRNA decay factors act in concert to regulate common mRNA targets. Rehwinkel J, et al. RNA, 2005 Oct. PMID 16199763, Free PMC Article
    4. Genome-wide analysis of nuclear mRNA export pathways in Drosophila. Herold A, et al. EMBO J, 2003 May 15. PMID 12743041, Free PMC Article
    5. The Extracellular and Cytoplasmic Domains of Syndecan Cooperate Postsynaptically to Promote Synapse Growth at the Drosophila Neuromuscular Junction. Nguyen MU, et al. PLoS One, 2016. PMID 26987116, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 3'-5' DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3'-5' DNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in regulation of alternative mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of U5 snRNP ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of small nuclear ribonucleoprotein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    obelus
    Names
    CG5205-PA
    obe-PA
    NP_650472.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      15486050..15493310
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142215.3 → NP_650472.2  obelus [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650472.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VF56
      Related
      FBpp0082601
      Conserved Domains (6) summary
      smart00490
      Location:1605 → 1704
      HELICc; helicase superfamily c-terminal domain
      smart00487
      Location:1332 → 1532
      DEXDc; DEAD-like helicases superfamily
      smart00611
      Location:1818 → 2176
      SEC63; Domain of unknown function in Sec63p, Brr2p and other proteins
      COG1204
      Location:450 → 1254
      BRR2; Replicative superfamily II helicase [Replication, recombination and repair]
      pfam00270
      Location:1338 → 1510
      DEAD; DEAD/DEAH box helicase
      pfam02889
      Location:989 → 1296
      Sec63; Sec63 Brl domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q961L2 Q961L2
    Q9VF56 Q9VF56

    Gene LinkOut

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