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    Nox NADPH oxidase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 5740310, updated on 9-Dec-2024

    Summary

    Official Symbol
    Noxprovided by FlyBase
    Official Full Name
    NADPH oxidaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0085428
    Locus tag
    Dmel_CG34399
    See related
    AllianceGenome:FB:FBgn0085428
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG15924; CG34399; CG3896; Dmel\CG34399; DmNox; dnox; dNox; nox; NOX; NOX-1; Nox1; NOX4; NOX5
    Old locus tag
    CG15924; CG3896; Dmel_CG15924; Dmel_CG3896
    Summary
    Predicted to enable superoxide-generating NAD(P)H oxidase activity. Involved in ovulation; positive regulation of calcium-mediated signaling; and positive regulation of smooth muscle contraction. Predicted to be part of NADPH oxidase complex. Predicted to be active in plasma membrane. Orthologous to human NOX5 (NADPH oxidase 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Nox in Genome Data Viewer
    Location:
    53B2-53B4; 2-79 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16307269..16316485)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12194774..12203990)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45232 Neighboring gene Autophagy-related 9 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables superoxide-generating NAD(P)H oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables superoxide-generating NAD(P)H oxidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in defense response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in ovulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of calcium-mediated signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of smooth muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in superoxide anion generation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of NADPH oxidase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    NADPH oxidase
    Names
    CG34399-PB
    CG34399-PC
    CG34399-PD
    CG34399-PE
    Nox-PB
    Nox-PC
    Nox-PD
    Nox-PE
    NP_001097336.1
    NP_001286485.1
    NP_001286486.1
    NP_611116.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      16307269..16316485
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299557.1NP_001286486.1  NADPH oxidase, isoform D [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DWJ8, G2J629
      Conserved Domains (6) summary
      cd06186
      Location:744819
      NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
      COG5126
      Location:314466
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      cd00051
      Location:365425
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam01794
      Location:560700
      Ferric_reduct; Ferric reductase like transmembrane component
      pfam08030
      Location:11581325
      NAD_binding_6; Ferric reductase NAD binding domain
      cl06868
      Location:11361178
      FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...
    2. NM_137272.2NP_611116.2  NADPH oxidase, isoform E [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DWJ8, G2J629
      Conserved Domains (6) summary
      cd06186
      Location:744819
      NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
      COG5126
      Location:314466
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      cd00051
      Location:365425
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam01794
      Location:560700
      Ferric_reduct; Ferric reductase like transmembrane component
      pfam08030
      Location:11581325
      NAD_binding_6; Ferric reductase NAD binding domain
      cl06868
      Location:11361178
      FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...
    3. NM_001299556.1NP_001286485.1  NADPH oxidase, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LFI7, G2J629
      Conserved Domains (5) summary
      cd06186
      Location:744819
      NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
      COG5126
      Location:314466
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      cd00051
      Location:365425
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam01794
      Location:560700
      Ferric_reduct; Ferric reductase like transmembrane component
      pfam08030
      Location:11001267
      NAD_binding_6; Ferric reductase NAD binding domain
    4. NM_001103866.2NP_001097336.1  NADPH oxidase, isoform C [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DWJ8, G2J629
      Conserved Domains (6) summary
      cd06186
      Location:744819
      NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
      COG5126
      Location:314466
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      cd00051
      Location:365425
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam01794
      Location:560700
      Ferric_reduct; Ferric reductase like transmembrane component
      pfam08030
      Location:11581325
      NAD_binding_6; Ferric reductase NAD binding domain
      cl06868
      Location:11361178
      FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...