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    CG43867 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31031, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG43867provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0264449
    Locus tag
    Dmel_CG43867
    See related
    AllianceGenome:FB:FBgn0264449
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12467; CG14632; CG14633; CG42248; Dmel\CG43867; EG:34F3.1; EG:34F3.2
    Old locus tag
    Dmel_CG12467; Dmel_CG14632; Dmel_CG14633; Dmel_CG42248
    Summary
    Predicted to be located in cytoskeleton. Is expressed in spermatozoon. Orthologous to human PLEKHH1 (pleckstrin homology, MyTH4 and FERM domain containing H1) and PLEKHH2 (pleckstrin homology, MyTH4 and FERM domain containing H2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG43867 in Genome Data Viewer
    Location:
    1C5-1D2; 1-0 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (808217..927975, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (702250..822008, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Secretory 22 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Leucine zipper like transcription regulator 1 Neighboring gene uncharacterized protein Neighboring gene Mediator complex subunit 22 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila polytene chromosome bands formed by gene introns. Zhimulev IF, et al. Dokl Biochem Biophys, 2016. PMID 27025489
    2. Genes Containing Long Introns Occupy Series of Bands and Interbands In Drosophila melanogaster polytene Chromosomes. Khoroshko VA, et al. Genes (Basel), 2020 Apr 11. PMID 32290448, Free PMC Article
    3. Global analysis of the relationship between JIL-1 kinase and transcription. Regnard C, et al. PLoS Genet, 2011 Mar. PMID 21423663, Free PMC Article
    4. PI(4)P Promotes Phosphorylation and Conformational Change of Smoothened through Interaction with Its C-terminal Tail. Jiang K, et al. PLoS Biol, 2016 Feb. PMID 26863604, Free PMC Article
    5. Genome wide identification of fruitless targets suggests a role in upregulating genes important for neural circuit formation. Vernes SC. Sci Rep, 2014 Mar 19. PMID 24642956, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    mobile_element

    • Loc: c848897-848851 mobile_element_type = transposon:INE-1{}5313
    • Loc: c872850-872797 mobile_element_type = transposon:INE-1{}5316

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG43867-PA
    CG43867-PB
    CG43867-PC
    CG43867-PD
    CG43867-PF
    CG43867-PH
    CG43867-PI
    CG43867-PJ
    CG43867-PK
    CG43867-PL

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      808217..927975 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272180.1 → NP_001259109.1  uncharacterized protein Dmel_CG43867, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259109.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W5D0
      Conserved Domains (7) summary
      smart00139
      Location:1107 → 1326
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00233
      Location:966 → 1067
      PH; Pleckstrin homology domain
      smart00295
      Location:1339 → 1559
      B41; Band 4.1 homologues
      cd13282
      Location:860 → 955
      PH1_PLEKHH1_PLEKHH2; Pleckstrin homology (PH) domain containing, family H (with MyTH4 domain) members 1 and 2 (PLEKHH1) PH domain, repeat 1
      pfam00169
      Location:858 → 951
      PH; PH domain
      pfam00373
      Location:1443 → 1559
      FERM_M; FERM central domain
      cl17171
      Location:1555 → 1657
      PH-like; Pleckstrin homology-like domain

    2. NM_001272178.2 → NP_001259107.2  uncharacterized protein Dmel_CG43867, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259107.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W5D0
      Conserved Domains (7) summary
      smart00139
      Location:1107 → 1294
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00233
      Location:966 → 1067
      PH; Pleckstrin homology domain
      smart00295
      Location:1307 → 1527
      B41; Band 4.1 homologues
      cd13282
      Location:860 → 955
      PH1_PLEKHH1_PLEKHH2; Pleckstrin homology (PH) domain containing, family H (with MyTH4 domain) members 1 and 2 (PLEKHH1) PH domain, repeat 1
      pfam00169
      Location:858 → 951
      PH; PH domain
      pfam00373
      Location:1411 → 1527
      FERM_M; FERM central domain
      cl17171
      Location:1523 → 1625
      PH-like; Pleckstrin homology-like domain

    3. NM_001272175.1 → NP_001259104.1  uncharacterized protein Dmel_CG43867, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259104.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W5D0
      Conserved Domains (7) summary
      smart00139
      Location:1191 → 1378
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00233
      Location:1050 → 1151
      PH; Pleckstrin homology domain
      smart00295
      Location:1391 → 1611
      B41; Band 4.1 homologues
      cd13282
      Location:944 → 1039
      PH1_PLEKHH1_PLEKHH2; Pleckstrin homology (PH) domain containing, family H (with MyTH4 domain) members 1 and 2 (PLEKHH1) PH domain, repeat 1
      pfam00169
      Location:942 → 1035
      PH; PH domain
      pfam00373
      Location:1495 → 1611
      FERM_M; FERM central domain
      cl17171
      Location:1607 → 1709
      PH-like; Pleckstrin homology-like domain

    4. NM_001297833.1 → NP_001284762.1  uncharacterized protein Dmel_CG43867, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284762.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JDC1
      Conserved Domains (7) summary
      smart00139
      Location:1191 → 1410
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00233
      Location:1050 → 1151
      PH; Pleckstrin homology domain
      smart00295
      Location:1423 → 1643
      B41; Band 4.1 homologues
      cd13282
      Location:944 → 1039
      PH1_PLEKHH1_PLEKHH2; Pleckstrin homology (PH) domain containing, family H (with MyTH4 domain) members 1 and 2 (PLEKHH1) PH domain, repeat 1
      pfam00169
      Location:942 → 1035
      PH; PH domain
      pfam00373
      Location:1527 → 1643
      FERM_M; FERM central domain
      cl17171
      Location:1639 → 1741
      PH-like; Pleckstrin homology-like domain

    5. NM_001272179.1 → NP_001259108.1  uncharacterized protein Dmel_CG43867, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259108.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W5D0
      Conserved Domains (7) summary
      smart00139
      Location:1107 → 1294
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00233
      Location:966 → 1067
      PH; Pleckstrin homology domain
      smart00295
      Location:1307 → 1527
      B41; Band 4.1 homologues
      cd13282
      Location:860 → 955
      PH1_PLEKHH1_PLEKHH2; Pleckstrin homology (PH) domain containing, family H (with MyTH4 domain) members 1 and 2 (PLEKHH1) PH domain, repeat 1
      pfam00169
      Location:858 → 951
      PH; PH domain
      pfam00373
      Location:1411 → 1527
      FERM_M; FERM central domain
      cl17171
      Location:1523 → 1625
      PH-like; Pleckstrin homology-like domain

    6. NM_001272177.1 → NP_001259106.1  uncharacterized protein Dmel_CG43867, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259106.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W5D0
      Conserved Domains (7) summary
      smart00139
      Location:1075 → 1252
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00233
      Location:934 → 1035
      PH; Pleckstrin homology domain
      smart00295
      Location:1265 → 1485
      B41; Band 4.1 homologues
      cd13282
      Location:828 → 923
      PH1_PLEKHH1_PLEKHH2; Pleckstrin homology (PH) domain containing, family H (with MyTH4 domain) members 1 and 2 (PLEKHH1) PH domain, repeat 1
      pfam00169
      Location:826 → 919
      PH; PH domain
      pfam00373
      Location:1369 → 1485
      FERM_M; FERM central domain
      cl17171
      Location:1481 → 1583
      PH-like; Pleckstrin homology-like domain

    7. NM_001103390.2 → NP_001096860.2  uncharacterized protein Dmel_CG43867, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001096860.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8JUT7, A8JUT8, D8FT41, M9PDF0, M9PG59, M9PGC2, M9PGC6, M9PGJ1, M9PIN4, O77432, O77433, Q1RKT6, Q9W5D0
      Conserved Domains (7) summary
      smart00139
      Location:1159 → 1378
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00233
      Location:1018 → 1119
      PH; Pleckstrin homology domain
      smart00295
      Location:1391 → 1611
      B41; Band 4.1 homologues
      cd13282
      Location:912 → 1007
      PH1_PLEKHH1_PLEKHH2; Pleckstrin homology (PH) domain containing, family H (with MyTH4 domain) members 1 and 2 (PLEKHH1) PH domain, repeat 1
      pfam00169
      Location:910 → 1003
      PH; PH domain
      pfam00373
      Location:1495 → 1611
      FERM_M; FERM central domain
      cl17171
      Location:1607 → 1709
      PH-like; Pleckstrin homology-like domain

    8. NM_001272176.1 → NP_001259105.1  uncharacterized protein Dmel_CG43867, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259105.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W5D0
      Conserved Domains (7) summary
      smart00139
      Location:777 → 986
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00233
      Location:636 → 737
      PH; Pleckstrin homology domain
      smart00295
      Location:999 → 1219
      B41; Band 4.1 homologues
      cd13282
      Location:530 → 625
      PH1_PLEKHH1_PLEKHH2; Pleckstrin homology (PH) domain containing, family H (with MyTH4 domain) members 1 and 2 (PLEKHH1) PH domain, repeat 1
      pfam00169
      Location:528 → 621
      PH; PH domain
      pfam00373
      Location:1103 → 1219
      FERM_M; FERM central domain
      cl17171
      Location:1215 → 1317
      PH-like; Pleckstrin homology-like domain

    9. NM_058041.4 → NP_477389.4  uncharacterized protein Dmel_CG43867, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477389.4

      Status: REVIEWED

      Conserved Domains (7) summary
      smart00139
      Location:861 → 1048
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00233
      Location:720 → 821
      PH; Pleckstrin homology domain
      smart00295
      Location:1061 → 1281
      B41; Band 4.1 homologues
      cd13282
      Location:614 → 709
      PH1_PLEKHH1_PLEKHH2; Pleckstrin homology (PH) domain containing, family H (with MyTH4 domain) members 1 and 2 (PLEKHH1) PH domain, repeat 1
      pfam00169
      Location:612 → 705
      PH; PH domain
      pfam00373
      Location:1165 → 1281
      FERM_M; FERM central domain
      cl17171
      Location:1277 → 1379
      PH-like; Pleckstrin homology-like domain

    10. NM_001103391.1 → NP_001096861.1  uncharacterized protein Dmel_CG43867, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001096861.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W5D0
      Conserved Domains (7) summary
      smart00139
      Location:861 → 1080
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00233
      Location:720 → 821
      PH; Pleckstrin homology domain
      smart00295
      Location:1093 → 1313
      B41; Band 4.1 homologues
      cd13282
      Location:614 → 709
      PH1_PLEKHH1_PLEKHH2; Pleckstrin homology (PH) domain containing, family H (with MyTH4 domain) members 1 and 2 (PLEKHH1) PH domain, repeat 1
      pfam00169
      Location:612 → 705
      PH; PH domain
      pfam00373
      Location:1197 → 1313
      FERM_M; FERM central domain
      cl17171
      Location:1309 → 1411
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W5D0.4 Q9W5D0
    X2JDC1 X2JDC1

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