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    Cnx14D Calnexin 14D [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32620, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cnx14Dprovided by FlyBase
    Official Full Name
    Calnexin 14Dprovided by FlyBase
    Primary source
    FLYBASE:FBgn0264077
    Locus tag
    Dmel_CG9906
    See related
    AllianceGenome:FB:FBgn0264077
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9906; Cnx; cnx14D; Dmel\CG9906; Xcbp1
    Summary
    Predicted to enable calcium ion binding activity and unfolded protein binding activity. Predicted to be involved in ERAD pathway and protein folding. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane. Is expressed in adult head; peripheral nervous system; and presumptive embryonic/larval central nervous system. Orthologous to human CLGN (calmegin) and CANX (calnexin). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cnx14D in Genome Data Viewer
    Location:
    14E1-14E1; 1-54 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (16522967..16525415, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16417000..16419448, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene eukaryotic translation initiation factor 4H1 Neighboring gene paralytic Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nucleotide sequence of a Drosophila melanogaster cDNA encoding a calnexin homologue. Christodoulou S, et al. Gene, 1997 Jun 3. PMID 9218712
    2. Identification of functionally distinct macrophage subpopulations in Drosophila. Coates JA, et al. Elife, 2021 Apr 22. PMID 33885361, Free PMC Article
    3. An inexpensive, scalable behavioral assay for measuring ethanol sedation sensitivity and rapid tolerance in Drosophila. Sandhu S, et al. J Vis Exp, 2015 Apr 15. PMID 25939022, Free PMC Article
    4. Drosophila as a model for epilepsy: bss is a gain-of-function mutation in the para sodium channel gene that leads to seizures. Parker L, et al. Genetics, 2011 Feb. PMID 21115970, Free PMC Article
    5. Molecular characterization of neurally expressing genes in the para sodium channel gene cluster of drosophila. Hong CS, et al. Genetics, 1996 Mar. PMID 8849894, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables unfolded protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein folding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    calnexin 14D
    Names
    CG9906-PA
    Cnx14D-PA
    calnexin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      16522967..16525415 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132903.3 → NP_573131.1  calnexin 14D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573131.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VXF6
      Related
      FBpp0074074
      Conserved Domains (1) summary
      pfam00262
      Location:59 → 432
      Calreticulin; Calreticulin family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VXF6 Q9VXF6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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