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    ara araucan [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39439, updated on 27-Dec-2024

    Summary

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    Official Symbol
    araprovided by FlyBase
    Official Full Name
    araucanprovided by FlyBase
    Primary source
    FLYBASE:FBgn0015904
    Locus tag
    Dmel_CG10571
    See related
    AllianceGenome:FB:FBgn0015904
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Ara; CG10571; Dmel\CG10571; iro; Iro; iro-C; Iro-C; IRO-C; IroC
    Summary
    Enables DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in several processes, including dendrite morphogenesis; positive regulation of transcription by RNA polymerase II; and wing disc development. Located in cytoplasm. Is expressed in several structures, including imaginal disc; photoreceptor neurons; presumptive wing vein; segment; and transverse muscle cell. Human ortholog(s) of this gene implicated in congenital heart disease. Orthologous to several human genes including IRX6 (iroquois homeobox 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ara in Genome Data Viewer
    Location:
    69C8-69C10; 3-38 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (12580672..12596018)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (12573772..12589118)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43612 Neighboring gene uncharacterized protein Neighboring gene Phosphomannomutase type 2 Neighboring gene sosondowah Neighboring gene caupolican Neighboring gene long non-coding RNA:CR32111

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. 2D gene expression parameters of wing imaginal disc of Drosophila for developmental analysis. Santarén JF, et al. Dev Genes Evol, 1996 Dec. PMID 24173594
    2. Iroquois transcription factors recognize a unique motif to mediate transcriptional repression in vivo. Bilioni A, et al. Proc Natl Acad Sci U S A, 2005 Oct 11. PMID 16203991, Free PMC Article
    3. Prepatterning the Drosophila notum: the three genes of the iroquois complex play intrinsically distinct roles. Ikmi A, et al. Dev Biol, 2008 May 15. PMID 18394597
    4. Apposition of iroquois expressing and non-expressing cells leads to cell sorting and fold formation in the Drosophila imaginal wing disc. Villa-Cuesta E, et al. BMC Dev Biol, 2007 Sep 19. PMID 17880703, Free PMC Article
    5. The iroquois complex controls the somatotopy of Drosophila notum mechanosensory projections. Grillenzoni N, et al. Development, 1998 Sep. PMID 9716522

    See all (194) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that genes araucan and caupolican as novel muscle identity genes that confer lateral transverse muscle identity, and the acquisition of this fate requires that Araucan/Caupolican repress other muscle identity genes such as slouch and vestigial.
      Title: Drosophila araucan and caupolican integrate intrinsic and signalling inputs for the acquisition by muscle progenitors of the lateral transverse fate.
    2. When caupolican and/or mirror expression is reduced, araucan loss of function has an effect on thoracic bristles development. Moreover, the overexpression of araucan is able to rescue caupolican loss of function.
      Title: Prepatterning the Drosophila notum: the three genes of the iroquois complex play intrinsically distinct roles.
    3. The data support a model in which the EGFR and Dpp signalling pathways, with their respective downstream Iro-C and tup genes, converge and cooperate to commit cells to the notum developmental fate.
      Title: tailup, a LIM-HD gene, and Iro-C cooperate in Drosophila dorsal mesothorax specification.
    4. Mutual repression between msh and Iro-C is an essential component of the boundary between body wall and wing in Drosophila.
      Title: Mutual repression between msh and Iro-C is an essential component of the boundary between body wall and wing in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in compound eye morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in equator specification TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing vein specification IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in muscle cell fate commitment IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in notum cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    araucan
    Names
    CG10571-PA
    CG10571-PB
    ara-PA
    ara-PB
    aracucan
    auracan
    iroquis complex
    iroquois
    iroquois gene complex
    iroquois-complex

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      12580672..12596018
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079321.3 → NP_524045.2  araucan, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524045.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24248, Q9VTZ9
      Related
      FBpp0075640
      Conserved Domains (1) summary
      pfam05920
      Location:273 → 312
      Homeobox_KN; Homeobox KN domain

    2. NM_001169961.2 → NP_001163432.1  araucan, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163432.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JHZ0
      Conserved Domains (1) summary
      pfam05920
      Location:265 → 304
      Homeobox_KN; Homeobox KN domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1JHZ0 E1JHZ0
    Q24248.2 Q24248
    Q5U114 Q5U114
    Q86NL5 Q86NL5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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