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    Dscam3 Down syndrome cell adhesion molecule 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42103, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dscam3provided by FlyBase
    Official Full Name
    Down syndrome cell adhesion molecule 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0261046
    Locus tag
    Dmel_CG31190
    See related
    AllianceGenome:FB:FBgn0261046
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12536; CG31190; CG8106; CT33960; Dmel\CG31190; DSCAM; Dscam-like
    Summary
    Enables identical protein binding activity. Predicted to be involved in homophilic cell adhesion via plasma membrane adhesion molecules and nervous system development. Predicted to be active in axon and plasma membrane. Is expressed in adult head and spermatozoon. Orthologous to human DSCAML1 (DS cell adhesion molecule like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Dscam3 in Genome Data Viewer
    Location:
    90B1-90B1; 3-61 cM
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (17473935..17505667, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (13299657..13331389, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Eclosion hormone Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44349 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The evolution of Dscam genes across the arthropods. Armitage SA, et al. BMC Evol Biol, 2012 Apr 13. PMID 22500922, Free PMC Article
    2. A honey bee Dscam family member, AbsCAM, is a brain-specific cell adhesion molecule with the neurite outgrowth activity which influences neuronal wiring during development. Funada M, et al. Eur J Neurosci, 2007 Jan. PMID 17241278
    3. Dscam-mediated cell recognition regulates neural circuit formation. Hattori D, et al. Annu Rev Cell Dev Biol, 2008. PMID 18837673, Free PMC Article
    4. Dscam2 mediates axonal tiling in the Drosophila visual system. Millard SS, et al. Nature, 2007 Jun 7. PMID 17554308, Free PMC Article
    5. All Creatures Great and Small: New Approaches for Understanding Down Syndrome Genetics. Moyer AJ, et al. Trends Genet, 2021 May. PMID 33097276, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cell-cell adhesion mediator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in central nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dendrite self-avoidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IC
    Inferred by Curator
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    down syndrome cell adhesion molecule 3
    Names
    CG31190-PC
    CG31190-PD
    CG31190-PE
    CG31190-PF
    Dscam3-PC
    Dscam3-PD
    Dscam3-PE
    Dscam3-PF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      17473935..17505667 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_206504.2 → NP_996226.2  down syndrome cell adhesion molecule 3, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996226.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KSE9
      Conserved Domains (9) summary
      cd00096
      Location:456 → 533
      Ig; Immunoglobulin domain
      smart00408
      Location:553 → 619
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:56 → 133
      IG; Immunoglobulin
      smart00410
      Location:734 → 815
      IG_like; Immunoglobulin like
      cd00063
      Location:1441 → 1530
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:246 → 337
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:1150 → 1237
      fn3; Fibronectin type III domain
      pfam00047
      Location:645 → 712
      ig; Immunoglobulin domain
      cl11960
      Location:838 → 920
      Ig; Immunoglobulin domain

    2. NM_169761.2 → NP_732242.2  down syndrome cell adhesion molecule 3, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732242.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VEJ5
      Conserved Domains (9) summary
      cd00096
      Location:456 → 533
      Ig; Immunoglobulin domain
      smart00408
      Location:553 → 619
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:56 → 133
      IG; Immunoglobulin
      smart00410
      Location:734 → 815
      IG_like; Immunoglobulin like
      cd00063
      Location:1441 → 1530
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:246 → 337
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:1150 → 1237
      fn3; Fibronectin type III domain
      pfam00047
      Location:645 → 712
      ig; Immunoglobulin domain
      cl11960
      Location:838 → 920
      Ig; Immunoglobulin domain

    3. NM_001104355.2 → NP_001097825.1  down syndrome cell adhesion molecule 3, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097825.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JR35
      Conserved Domains (9) summary
      cd00096
      Location:456 → 533
      Ig; Immunoglobulin domain
      smart00408
      Location:553 → 643
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:56 → 133
      IG; Immunoglobulin
      smart00410
      Location:758 → 839
      IG_like; Immunoglobulin like
      cd00063
      Location:1465 → 1554
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:246 → 337
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:1174 → 1261
      fn3; Fibronectin type III domain
      pfam00047
      Location:669 → 736
      ig; Immunoglobulin domain
      cl11960
      Location:862 → 944
      Ig; Immunoglobulin domain

    4. NM_001104356.2 → NP_001097826.1  down syndrome cell adhesion molecule 3, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097826.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6IDE9
      Conserved Domains (8) summary
      cd00096
      Location:456 → 533
      Ig; Immunoglobulin domain
      smart00408
      Location:553 → 619
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:56 → 133
      IG; Immunoglobulin
      smart00410
      Location:734 → 815
      IG_like; Immunoglobulin like
      cd00063
      Location:917 → 955
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:246 → 337
      I-set; Immunoglobulin I-set domain
      pfam00047
      Location:645 → 712
      ig; Immunoglobulin domain
      cl11960
      Location:838 → 920
      Ig; Immunoglobulin domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8JR35 A8JR35
    Q6IDE9 Q6IDE9
    Q7KSE9 Q7KSE9
    Q9VEJ5 Q9VEJ5

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