Srp54k Signal recognition particle 54k [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Srp54kprovided by FlyBase
Official Full Name: Signal recognition particle 54kprovided by FlyBase
Primary source: FLYBASE:FBgn0010747
Locus tag: Dmel_CG4659
See related: AllianceGenome:FB:FBgn0010747
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA.GM09489; BcDNA:GM09489; CG4659; Dmel\CG4659; l(3)01418; Srp54
Summary: Predicted to enable 7S RNA binding activity and endoplasmic reticulum signal peptide binding activity. Predicted to contribute to GTPase activity. Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane, translocation. Predicted to be part of signal recognition particle, endoplasmic reticulum targeting. Predicted to be active in cytosol. Is expressed in adult head; presumptive embryonic salivary gland; and salivary gland body primordium. Human ortholog(s) of this gene implicated in severe congenital neutropenia 8. Orthologous to human SRP54 (signal recognition particle 54). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (5152678..5154777)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (5145778..5147877)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables 7S RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables 7S RNA binding	IEA Inferred from Electronic Annotation more info
enables 7S RNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
contributes_to GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables endoplasmic reticulum signal peptide binding	IBA Inferred from Biological aspect of Ancestor more info
enables endoplasmic reticulum signal peptide binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in SRP-dependent cotranslational protein targeting to membrane	IEA Inferred from Electronic Annotation more info
involved_in SRP-dependent cotranslational protein targeting to membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in SRP-dependent cotranslational protein targeting to membrane, translocation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
part_of signal recognition particle	IEA Inferred from Electronic Annotation more info
part_of signal recognition particle, endoplasmic reticulum targeting	IBA Inferred from Biological aspect of Ancestor more info
part_of signal recognition particle, endoplasmic reticulum targeting	ISS Inferred from Sequence or Structural Similarity more info

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The following sections contain reference sequences that belong to a specific genome build. Explain