Atg12 Autophagy-related 12 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Atg12provided by FlyBase
Official Full Name: Autophagy-related 12provided by FlyBase
Primary source: FLYBASE:FBgn0036255
Locus tag: Dmel_CG10861
See related: AllianceGenome:FB:FBgn0036255
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: atg12; ATG12; CG10861; Dmel\CG10861
Summary: Predicted to enable protein tag activity. Predicted to contribute to Atg8-family ligase activity. Involved in cellular response to starvation; glycophagy; and larval midgut cell programmed cell death. Predicted to be located in cytoplasm. Predicted to be part of Atg12-Atg5-Atg16 complex. Predicted to be active in autophagosome membrane and phagophore assembly site membrane. Is expressed in ovary. Orthologous to human ATG12 (autophagy related 12). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (12136967..12137559)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (12130067..12130659)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
contributes_to Atg8-family ligase activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to Atg8-family ligase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein tag activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tag activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in autophagosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagosome assembly	IEA Inferred from Electronic Annotation more info
involved_in autophagosome assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in autophagosome maturation	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in autophagy of mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glycophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval midgut cell programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in macroautophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in piecemeal microautophagy of the nucleus	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of Atg12-Atg5-Atg16 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Atg12-Atg5-Atg16 complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in autophagosome membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in phagophore assembly site membrane	IBA Inferred from Biological aspect of Ancestor more info

Names: Atg12-PB; Autophagy-specific gene 12; CG10861-PB; autophagy related protein 12

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The following sections contain reference sequences that belong to a specific genome build. Explain