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    CG8004 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40178, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG8004provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036920
    Locus tag
    Dmel_CG8004
    See related
    AllianceGenome:FB:FBgn0036920
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG8004
    Summary
    Predicted to be involved in mitochondrial outer membrane translocase complex assembly. Predicted to be part of SAM complex. Predicted to be active in cytoplasm. Is expressed in adult head. Orthologous to human MTX2 (metaxin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG8004 in Genome Data Viewer
    Location:
    76D5-76D5; 3-46 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (19927194..19928508, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (19920294..19921608, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Prefoldin 6 Neighboring gene Grasp65 Neighboring gene RhoGDI Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45678

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolution and structural organization of the mitochondrial contact site (MICOS) complex and the mitochondrial intermembrane space bridging (MIB) complex. Huynen MA, et al. Biochim Biophys Acta, 2016 Jan. PMID 26477565
    2. Amyotrophic Lateral Sclerosis Modifiers in Drosophila Reveal the Phospholipase D Pathway as a Potential Therapeutic Target. Kankel MW, et al. Genetics, 2020 Jul. PMID 32345615, Free PMC Article
    3. Molecular genetic analysis of Chd3 and polytene chromosome region 76B-D in Drosophila melanogaster. Cooper MT, et al. Genetics, 2010 Jul. PMID 20439780, Free PMC Article
    4. Genome-wide analysis in Drosophila reveals age-specific effects of SNPs on fitness traits. Durham MF, et al. Nat Commun, 2014 Jul 8. PMID 25000897
    5. Putative synaptic genes defined from a Drosophila whole body developmental transcriptome by a machine learning approach. Pazos Obregón F, et al. BMC Genomics, 2015 Sep 15. PMID 26370122, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in mitochondrial outer membrane translocase complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitochondrion organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of SAM complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SAM complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of SAM complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG8004-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      19927194..19928508 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140904.2 → NP_649161.1  uncharacterized protein Dmel_CG8004 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649161.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VW58
      Related
      FBpp0074684
      Conserved Domains (2) summary
      cd03211
      Location:130 → 258
      GST_C_Metaxin2; C-terminal, alpha helical domain of Metaxin 2
      cd03079
      Location:24 → 100
      GST_N_Metaxin2; GST_N family, Metaxin subfamily, Metaxin 2; a metaxin 1 binding protein identified through a yeast two-hybrid system using metaxin 1 as the bait. Metaxin 2 shares sequence similarity with metaxin 1 but does not contain a C-terminal mitochondrial outer ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VW58 Q9VW58

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