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    JhI-21 Juvenile hormone Inducible-21 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34624, updated on 9-Dec-2024

    Summary

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    Official Symbol
    JhI-21provided by FlyBase
    Official Full Name
    Juvenile hormone Inducible-21provided by FlyBase
    Primary source
    FLYBASE:FBgn0028425
    Locus tag
    Dmel_CG12317
    See related
    AllianceGenome:FB:FBgn0028425
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12317; Dmel\CG12317; JHI-21; jhl-21; Jhl-21
    Summary
    Predicted to enable L-amino acid transmembrane transporter activity. Involved in several processes, including L-leucine import across plasma membrane; cellular response to L-leucine; and positive regulation of insulin secretion. Predicted to be located in membrane. Is expressed in several structures, including adult head; embryonic/larval motor neurons; embryonic/larval neuromuscular junction; ganglia; and larval central nervous system. Human ortholog(s) of this gene implicated in cholangiocarcinoma; colon cancer; hepatocellular carcinoma; and lung squamous cell carcinoma. Orthologous to several human genes including SLC7A5 (solute carrier family 7 member 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See JhI-21 in Genome Data Viewer
    Location:
    33B11-33C1; 2-46 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (12051755..12056042, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (12051755..12056042, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44589 Neighboring gene Promyelocytic leukemia zinc finger Neighboring gene Phosphatidylinositol-specific phospholipase C X domain containing Neighboring gene Ribosomal protein L7-like Neighboring gene uncharacterized protein Neighboring gene Rab3 GTPase activating protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Hemolymph amino acid variations following behavioral and genetic changes in individual Drosophila larvae. Piyankarage SC, et al. Amino Acids, 2010 Mar. PMID 19360460
    2. JhI-21 plays a role in Drosophila insulin-like peptide release from larval IPCs via leucine transport. Ziegler AB, et al. Sci Rep, 2018 Jan 30. PMID 29382949, Free PMC Article
    3. Juvenile hormone signaling during oogenesis in Drosophila melanogaster. Dubrovsky EB, et al. Insect Biochem Mol Biol, 2002 Nov. PMID 12530223
    4. Hormonal regulation and functional role of Drosophila E75A orphan nuclear receptor in the juvenile hormone signaling pathway. Dubrovsky EB, et al. Dev Biol, 2004 Apr 15. PMID 15063166
    5. Serotonin signaling mediates protein valuation and aging. Ro J, et al. Elife, 2016 Aug 23. PMID 27572262, Free PMC Article

    See all (64) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. JNK and Yorkie drive tumor malignancy by inducing L-amino acid transporter 1 in Drosophila.
      Title: JNK and Yorkie drive tumor malignancy by inducing L-amino acid transporter 1 in Drosophila.
    2. Data show that CG2791 and two Drosophila homologues of the mammalian CD98 light chains, Mnd (Minidiscs) and JhI-21, are required for normal levels of System L transport.
      Title: Drosophila expresses a CD98 transporter with an evolutionarily conserved structure and amino acid-transport properties.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables L-amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-leucine import across plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in amino acid transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in carbohydrate homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to L-leucine IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in defense response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of insulin secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    juvenile hormone Inducible-21
    Names
    CG12317-PA
    CG12317-PB
    CG12317-PC
    CG12317-PD
    CG12317-PE
    JhI-21-PA
    JhI-21-PB
    JhI-21-PC
    JhI-21-PD
    JhI-21-PE
    solute carrier 7-family amino acid transporter

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      12051755..12056042 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298935.1 → NP_001285864.1  juvenile hormone Inducible-21, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285864.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VKC2
      Conserved Domains (1) summary
      cl26159
      Location:27 → 494
      AA_permease_2; Amino acid permease

    2. NM_135698.4 → NP_609542.1  juvenile hormone Inducible-21, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609542.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VKC2
      Related
      FBpp0088598
      Conserved Domains (1) summary
      cl26159
      Location:27 → 494
      AA_permease_2; Amino acid permease

    3. NM_164988.4 → NP_723717.2  juvenile hormone Inducible-21, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723717.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VKC2
      Related
      FBpp0088925
      Conserved Domains (1) summary
      cl26159
      Location:27 → 494
      AA_permease_2; Amino acid permease

    4. NM_001298934.1 → NP_001285863.1  juvenile hormone Inducible-21, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285863.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VKC2
      Conserved Domains (1) summary
      cl26159
      Location:27 → 494
      AA_permease_2; Amino acid permease

    5. NM_001259067.1 → NP_001245996.1  juvenile hormone Inducible-21, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245996.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VKC2
      Conserved Domains (1) summary
      cl26159
      Location:27 → 494
      AA_permease_2; Amino acid permease
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VKC2 Q9VKC2

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