nAChRbeta2 nicotinic Acetylcholine Receptor beta2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: nAChRbeta2provided by FlyBase
Official Full Name: nicotinic Acetylcholine Receptor beta2provided by FlyBase
Primary source: FLYBASE:FBgn0004118
Locus tag: Dmel_CG6798
See related: AllianceGenome:FB:FBgn0004118
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Acr96Ac; AcrF; beta2; beta[[2]]; CG6798; Dbeta2; Dmel\CG6798; EMS2; nAChR; nAChR-beta96A; nACR beta 96A; nAcr96Ac; nAcRbeta; nACRbeta; nAcRbeta-96A; nAcRs; sbd; SBD
Summary: Predicted to enable acetylcholine-gated monoatomic cation-selective channel activity. Involved in cholinergic synaptic transmission and response to insecticide. Predicted to be located in postsynaptic membrane. Predicted to be part of acetylcholine-gated channel complex. Predicted to be active in neuron projection; plasma membrane; and synapse. Is expressed in adult head; lobula; lobula plate; medulla; and transmedullary neuron Tm2. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; autosomal dominant nocturnal frontal lobe epilepsy (multiple); congenital myasthenic syndrome (multiple); gastrointestinal system cancer (multiple); and respiratory system cancer (multiple). Orthologous to several human genes including CHRNA6 (cholinergic receptor nicotinic alpha 6 subunit). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 96A5-96A5; 3-85 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (24509228..24515106, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (20334950..20340828, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

mutation can confer nitenpyram resistance
Title: Mutations in Dalpha1 or Dbeta2 nicotinic acetylcholine receptor subunits can confer resistance to neonicotinoids in Drosophila melanogaster.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables acetylcholine-gated monoatomic cation-selective channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables acetylcholine-gated monoatomic cation-selective channel activity	IEA Inferred from Electronic Annotation more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of membrane potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to insecticide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic transmission, cholinergic	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
part_of acetylcholine-gated channel complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: nicotinic acetylcholine receptor beta2

Names: CG6798-PA; CG6798-PB; Dbeta2; SBD; nAChRbeta2-PA; nAChRbeta2-PB; nicotinic acetylcholine receptor beta 96A; second beta-like subunit of drosophila

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

24509228..24515106 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079759.4 → NP_524483.1 nicotinic acetylcholine receptor beta2, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524483.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O18403, P25162, Q8IMW6, Q8SXP7, Q9VC71

Related

FBpp0084061

Conserved Domains (2) summary

TIGR00860
Location:9 → 479

LIC; Cation transporter family protein

cd19031
Location:29 → 247

LGIC_ECD_nAChR_proto_alpha-like; extracellular domain of nicotinic acetylcholine receptor subunit alpha-like found in protostomia
NM_170147.3 → NP_733002.1 nicotinic acetylcholine receptor beta2, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_733002.1

Status: REVIEWED

UniProtKB/TrEMBL

H5V857

Related

FBpp0084062

Conserved Domains (2) summary

pfam02931
Location:31 → 245

Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain

pfam02932
Location:252 → 278

Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region