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    holn1 hole-in-one [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34432, updated on 9-Dec-2024

    Summary

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    Official Symbol
    holn1provided by FlyBase
    Official Full Name
    hole-in-oneprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032250
    Locus tag
    Dmel_CG5198
    See related
    AllianceGenome:FB:FBgn0032250
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5198; Dmel\CG5198
    Summary
    Involved in several processes, including chaeta development; compound eye development; and positive regulation of wound healing. Located in nucleus. Is expressed in organism. Orthologous to human CD2BP2 (CD2 cytoplasmic tail binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See holn1 in Genome Data Viewer
    Location:
    31E2-31E2; 2-42 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10435995..10437316)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10435995..10437316)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Basal body up regulated gene 22 Neighboring gene Transcription factor IIB Neighboring gene TBC1 domain family member 16 Neighboring gene STIP1 homology and U-box containing protein 1 Neighboring gene Non-SMC element 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Hole-in-one mutant phenotypes link EGFR/ERK signaling to epithelial tissue repair in Drosophila. Geiger JA, et al. PLoS One, 2011. PMID 22140578, Free PMC Article
    2. Transposable elements contribute to the genomic response to insecticides in Drosophila melanogaster. Salces-Ortiz J, et al. Philos Trans R Soc Lond B Biol Sci, 2020 Mar 30. PMID 32075557, Free PMC Article
    3. Genetic screen in Drosophila melanogaster uncovers a novel set of genes required for embryonic epithelial repair. Campos I, et al. Genetics, 2010 Jan. PMID 19884309, Free PMC Article
    4. High-resolution protein interaction map of the Drosophila melanogaster p38 mitogen-activated protein kinases reveals limited functional redundancy. Belozerov VE, et al. Mol Cell Biol, 2012 Sep. PMID 22801366, Free PMC Article
    5. Population distribution analyses reveal a hierarchy of molecular players underlying parallel endocytic pathways. Gupta GD, et al. PLoS One, 2014. PMID 24971745, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Holn1 acts downstream of EGFR and ERK signaling in the Grh/Fos mediated wound closure pathway.
      Title: Hole-in-one mutant phenotypes link EGFR/ERK signaling to epithelial tissue repair in Drosophila.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in chaeta development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in compound eye development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of wound healing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in wing disc development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in wound healing HMP PubMed 
    Component Evidence Code Pubs
    part_of U5 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U5 snRNP IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of U5 snRNP ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    hole-in-one
    Names
    CG5198-PA
    holn1-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      10435995..10437316
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135560.3 → NP_609404.2  hole-in-one [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609404.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C4XVH8, Q8T0Q7, Q9VKV5
      Related
      FBpp0079616
      Conserved Domains (1) summary
      cd00072
      Location:260 → 318
      GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VKV5.1 Q9VKV5

    Gene LinkOut

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    Chemical Information
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