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    mthl12 methuselah-like 12 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 261599, updated on 9-Dec-2024

    Summary

    Official Symbol
    mthl12provided by FlyBase
    Official Full Name
    methuselah-like 12provided by FlyBase
    Primary source
    FLYBASE:FBgn0045442
    Locus tag
    Dmel_CG32853
    See related
    AllianceGenome:FB:FBgn0045442
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG32853; Dmel\CG32853; Mthl12
    Summary
    Predicted to enable G protein-coupled peptide receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway; determination of adult lifespan; and response to starvation. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See mthl12 in Genome Data Viewer
    Location:
    87E7-87E7; 3-53 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (13353673..13355413)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (9179395..9181135)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Pyrokinin 2 receptor 2 Neighboring gene Pyrokinin 2 receptor 1 Neighboring gene Elongator complex protein 6 Neighboring gene Dicarboxylate carrier 1 Neighboring gene Chemosensory protein A 87a Neighboring gene Lipase 3

    Genomic regions, transcripts, and products

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables G protein-coupled peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables G protein-coupled receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in determination of adult lifespan ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to starvation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    methuselah-like 12
    Names
    CG32853-PA
    Mth-like 12
    Mth-like-12
    mthl12-PA

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      13353673..13355413
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169508.2NP_731791.2  methuselah-like 12 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731791.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P83119, Q8INH4
      Related
      FBpp0082214, FBtr0082746
      Conserved Domains (1) summary
      pfam06652
      Location:27209
      Methuselah_N; Methuselah N-terminus