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    Datp Diadenosine tetraphosphatase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 318908, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Datpprovided by FlyBase
    Official Full Name
    Diadenosine tetraphosphataseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0287788
    Locus tag
    Dmel_CG31713
    See related
    AllianceGenome:FB:FBgn0287788
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Apf; Ap[[4]]A; CG31713; Dmel\CG31713; FB2020_03; IP04585
    Summary
    Predicted to enable bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity. Predicted to be involved in AMP biosynthetic process and ATP biosynthetic process. Is expressed in adult head and oocyte. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Datp in Genome Data Viewer
    Location:
    30F1-30F1; 2-38 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (9938178..9938790, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (9938178..9938790, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Cuticular protein 30F Neighboring gene Arginine and glutamate rich 1 Neighboring gene antisense RNA:CR45007 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45949 Neighboring gene mir-87 stem loop

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Diadenosine 5",5"'P1,P4-tetraphosphatase in Drosophila embryos: developmental regulation and characterization. Vallejo CG, et al. Int J Biochem, 1989. PMID 2558922
    2. Adipose tissue coregulates cognitive function. Oliveras-Cañellas N, et al. Sci Adv, 2023 Aug 11. PMID 37566655, Free PMC Article
    3. GWAS reveal a role for the central nervous system in regulating weight and weight change in response to exercise. Watanabe LP, et al. Sci Rep, 2021 Mar 4. PMID 33664357, Free PMC Article
    4. Ancient Male Recombination Shaped Genetic Diversity of Neo-Y Chromosome in Drosophila albomicans. Satomura K, et al. Mol Biol Evol, 2016 Feb. PMID 26494844
    5. Impaired retrograde transport by the Dynein/Dynactin complex contributes to Tau-induced toxicity. Butzlaff M, et al. Hum Mol Genet, 2015 Jul 1. PMID 25794683

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables bis(5'-nucleosyl)-tetraphosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in AMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ATP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    diadenosine tetraphosphatase
    Names
    CG31713-PA
    Datp-PA
    diadenosine tetraphosphate hydrolase
    NP_723505.2
    • unusual splice

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      9938178..9938790 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_164880.3 → NP_723505.2  diadenosine tetraphosphatase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723505.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V6I8, Q4V6M1, Q8IPD7
      Conserved Domains (1) summary
      cd03428
      Location:1 → 133
      Ap4A_hydrolase_human_like; Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4V6M1 Q4V6M1

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