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    Tmem214 Transmembrane protein 214 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34514, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tmem214provided by FlyBase
    Official Full Name
    Transmembrane protein 214provided by FlyBase
    Primary source
    FLYBASE:FBgn0053129
    Locus tag
    Dmel_CG33129
    See related
    AllianceGenome:FB:FBgn0053129
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG33129; CG6087; CG6089; Dmel\CG33129; dTMEM214
    Summary
    Involved in response to hyperoxia. Located in apical plasma membrane and microvillus membrane. Is expressed in several structures, including adult head; adult heart; antennal primordium; gut section; and head epidermis primordium. Orthologous to human TMEM214 (transmembrane protein 214). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Tmem214 in Genome Data Viewer
    Location:
    32C1-32C1; 2-44 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10964905..10970275, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10964905..10970275, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene defective proboscis extension response 2 Neighboring gene long non-coding RNA:CR44492 Neighboring gene long non-coding RNA:CR44493 Neighboring gene uncharacterized protein Neighboring gene YL-1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila transmembrane protein 214 (dTMEM214) regulates midgut glucose uptake and systemic glucose homeostasis. Li Y, et al. Dev Biol, 2023 Mar. PMID 36657508, Free PMC Article
    2. Review: Hypoxic and oxidative stress resistance in Drosophila melanogaster. Zhao HW, et al. Placenta, 2011 Mar. PMID 21353099, Free PMC Article
    3. Discovery of insect and human dengue virus host factors. Sessions OM, et al. Nature, 2009 Apr 23. PMID 19396146, Free PMC Article
    4. Experimental selection for Drosophila survival in extremely high O2 environments. Zhao HW, et al. PLoS One, 2010 Jul 23. PMID 20668515, Free PMC Article
    5. Organ-specific gene expression: the bHLH protein Sage provides tissue specificity to Drosophila FoxA. Fox RM, et al. Development, 2013 May. PMID 23578928, Free PMC Article

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Drosophila transmembrane protein 214 (dTMEM214) regulates midgut glucose uptake and systemic glucose homeostasis.
      Title: Drosophila transmembrane protein 214 (dTMEM214) regulates midgut glucose uptake and systemic glucose homeostasis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in response to hyperoxia IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endomembrane system HDA PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microvillus membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transmembrane protein 214
    Names
    CG33129-PA
    CG33129-PB
    CG33129-PC
    CG33129-PE
    CG33129-PF
    CG33129-PG
    CG33129-PH
    Tmem214-PA
    Tmem214-PB
    Tmem214-PC
    Tmem214-PE
    Tmem214-PF
    Tmem214-PG
    Tmem214-PH

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      10964905..10970275 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298891.1 → NP_001285820.1  transmembrane protein 214, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285820.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VKM7
      Conserved Domains (1) summary
      pfam10151
      Location:211 → 608
      DUF2359; uncharacterized conserved protein (DUF2359)

    2. NM_176010.3 → NP_788024.1  transmembrane protein 214, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788024.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VKM8
      Related
      FBpp0079759
      Conserved Domains (1) summary
      pfam10151
      Location:48 → 168
      DUF2359; uncharacterized conserved protein (DUF2359)

    3. NM_176011.3 → NP_788025.1  transmembrane protein 214, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788025.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VKM8
      Related
      FBpp0079760
      Conserved Domains (1) summary
      pfam10151
      Location:48 → 168
      DUF2359; uncharacterized conserved protein (DUF2359)

    4. NM_001298892.1 → NP_001285821.1  transmembrane protein 214, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285821.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VKM8
      Conserved Domains (1) summary
      pfam10151
      Location:48 → 168
      DUF2359; uncharacterized conserved protein (DUF2359)

    5. NM_001298893.1 → NP_001285822.1  transmembrane protein 214, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285822.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VKM8
      Conserved Domains (1) summary
      pfam10151
      Location:48 → 168
      DUF2359; uncharacterized conserved protein (DUF2359)

    6. NM_176012.3 → NP_788026.1  transmembrane protein 214, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788026.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VKM8
      Related
      FBpp0079761
      Conserved Domains (1) summary
      pfam10151
      Location:48 → 168
      DUF2359; uncharacterized conserved protein (DUF2359)

    7. NM_176009.3 → NP_788023.1  transmembrane protein 214, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788023.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VKM7
      Related
      FBpp0079758
      Conserved Domains (1) summary
      pfam10151
      Location:211 → 608
      DUF2359; uncharacterized conserved protein (DUF2359)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VKM7 Q9VKM7
    Q9VKM8 Q9VKM8

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