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    HP1b Heterochromatin Protein 1b [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31834, updated on 9-Dec-2024

    Summary

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    Official Symbol
    HP1bprovided by FlyBase
    Official Full Name
    Heterochromatin Protein 1bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030082
    Locus tag
    Dmel_CG7041
    See related
    AllianceGenome:FB:FBgn0030082
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7041; Dmel\CG7041; HP1; hp1b; Hp1b; HP1B
    Summary
    Enables chromatin binding activity. Involved in negative regulation of heterochromatin formation; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription by RNA polymerase II. Located in chromatin; chromocenter; and nucleus. Is expressed in several structures, including adult head; ganglia; and gonad. Orthologous to several human genes including CBX3 (chromobox 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See HP1b in Genome Data Viewer
    Location:
    8C4-8C4; 1-26 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (9081063..9082746)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (8975096..8976779)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Anaphase Promoting Complex subunit 4 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. HP1B is a euchromatic Drosophila HP1 homolog with links to metabolism. Mills BB, et al. PLoS One, 2018. PMID 30346969, Free PMC Article
    2. Chromatin remodeling in the aging genome of Drosophila. Wood JG, et al. Aging Cell, 2010 Dec. PMID 20961390, Free PMC Article
    3. Co-amplification of CBX3 with EGFR or RAC1 in human cancers corroborated by a conserved genetic interaction among the genes. Bosso G, et al. Cell Death Discov, 2023 Aug 26. PMID 37633946, Free PMC Article
    4. The Heterochromatin Protein 1 family. Lomberk G, et al. Genome Biol, 2006. PMID 17224041, Free PMC Article
    5. New genes important for development. Kemkemer C, et al. EMBO Rep, 2014 May. PMID 24723687, Free PMC Article

    See all (111) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HP1 associates differently with RNA polymerase II; HP1a and HP1b, but not HP1c, inhibit transcriptional activity, suggesting that HP1c serves as a positive regulator in transcription.
      Title: Comparison of three heterochromatin protein 1 homologs in Drosophila.
    2. genes with functions in various metabolic processes are affected primarily by HP1B loss; HP1B is a euchromatic Drosophila HP1 homolog with links to metabolism
      Title: HP1B is a euchromatic Drosophila HP1 homolog with links to metabolism.
    3. phenotypes that emerge in the context of wild-type levels of the HP1 and Mod(mdg4) proteins might be part of an adaptive response to the environment.
      Title: Chromatin-associated proteins HP1 and Mod(mdg4) modify Y-linked regulatory variation in the drosophila testis.
    4. Data indicate significant similarity and uniqueness in the genes regulated by three HP1 homologs HP1a, HP1b, and HP1c.
      Title: DNA microarray profiling of genes differentially regulated by three heterochromatin protein 1 (HP1) homologs in Drosophila.
    5. both activating and repressing roles for HP1 at Sxl(Pe).
      Title: Cooperative and antagonistic contributions of two heterochromatin proteins to transcriptional regulation of the Drosophila sex determination decision.
    6. HP1b counteracts HP1a function both in heterochromatin formation and in the transcriptional regulation of euchromatic genes.
      Title: Drosophila melanogaster heterochromatin protein HP1b plays important roles in transcriptional activation and development.
    7. These observations confirm an HP1 co-operative DNA-binding and display for the first time the HP1 DNA target motif that, we hypothesize, should be one of its nucleation sites.
      Title: Heterochromatin protein 1 interacts with 5'UTR of transposable element ZAM in a sequence-specific fashion.
    8. The distribution of the HP1 protein depends on the SuUR gene.
      Title: The SuUR gene influences the distribution of heterochromatic proteins HP1 and SU(VAR)3-9 on nurse cell polytene chromosomes of Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables methylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in heterochromatin formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromocenter IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in euchromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in pericentric heterochromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    heterochromatin protein 1b
    Names
    CG7041-PA
    CG7041-PB
    CG7041-PC
    HP1b-PA
    HP1b-PB
    HP1b-PC
    heterochromatin protein 1B

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      9081063..9082746
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132293.3 → NP_572521.2  heterochromatin protein 1b, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572521.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95SE0, Q9W396
      Related
      FBpp0071221
      Conserved Domains (2) summary
      smart00298
      Location:3 → 52
      CHROMO; Chromatin organization modifier domain
      pfam01393
      Location:100 → 151
      Chromo_shadow; Chromo shadow domain

    2. NM_001258657.2 → NP_001245586.1  heterochromatin protein 1b, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245586.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95SE0, Q9W396
      Conserved Domains (2) summary
      smart00298
      Location:3 → 52
      CHROMO; Chromatin organization modifier domain
      pfam01393
      Location:100 → 151
      Chromo_shadow; Chromo shadow domain

    3. NM_001169242.2 → NP_001162713.1  heterochromatin protein 1b, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162713.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95SE0, Q9W396
      Conserved Domains (2) summary
      smart00298
      Location:3 → 52
      CHROMO; Chromatin organization modifier domain
      pfam01393
      Location:100 → 151
      Chromo_shadow; Chromo shadow domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95SE0 Q95SE0
    Q9W396 Q9W396

    Gene LinkOut

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