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    apn apnoia [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41631, updated on 9-Dec-2024

    Summary

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    Official Symbol
    apnprovided by FlyBase
    Official Full Name
    apnoiaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038132
    Locus tag
    Dmel_CG15887
    See related
    AllianceGenome:FB:FBgn0038132
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Apn; BcDNA:RE53127; CG15887; Dmel\CG15887
    Summary
    Involved in positive regulation of protein localization to membrane and respiratory system development. Located in apical plasma membrane. Is expressed in adult head; embryonic/larval tracheal section; larval tracheal system; and tracheal fusion cell. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See apn in Genome Data Viewer
    Location:
    87E4-87E4; 3-53 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (13287655..13288813, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (9113377..9114535, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Osiris 22 Neighboring gene wnt inhibitor of Dorsal

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The novel gene apnoia regulates Drosophila tracheal tube size. Scholl A, et al. Dev Dyn, 2019 Jun. PMID 30892787
    2. The apical protein Apnoia interacts with Crumbs to regulate tracheal growth and inflation. Skouloudaki K, et al. PLoS Genet, 2019 Jan. PMID 30645584, Free PMC Article
    3. Form and function of the apical extracellular matrix: new insights from Caenorhabditis elegans, Drosophila melanogaster, and the vertebrate inner ear. Li Zheng S, et al. Fac Rev, 2020. PMID 33659959, Free PMC Article
    4. Cells into tubes: Molecular and physical principles underlying lumen formation in tubular organs. Camelo C, et al. Curr Top Dev Biol, 2021. PMID 33820625
    5. Temperature, rainfall and wind variables underlie environmental adaptation in natural populations of Drosophila melanogaster. Bogaerts-Márquez M, et al. Mol Ecol, 2021 Feb. PMID 33350518, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in dorsal trunk growth, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in liquid clearance, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lumen formation, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in open tracheal system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein localization to membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in trachea development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in trachea development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    apnoia
    Names
    CG15887-PA
    apn-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      13287655..13288813 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142013.3 → NP_650270.1  apnoia [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650270.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VFX3
      Related
      FBpp0082244
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VFX3.1 Q9VFX3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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