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    CG31524 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 318781, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG31524provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0051524
    Locus tag
    Dmel_CG31524
    See related
    AllianceGenome:FB:FBgn0051524
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG31524
    Summary
    Predicted to enable procollagen-proline 4-dioxygenase activity. Predicted to be active in endoplasmic reticulum. Is expressed in adult head. Orthologous to human P4HA3 (prolyl 4-hydroxylase subunit alpha 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG31524 in Genome Data Viewer
    Location:
    99F6-99F7; 3-100 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (30512325..30514355, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (26338047..26340077, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene mir-4908 stem loop Neighboring gene uncharacterized protein Neighboring gene prolyl-4-hydroxylase-alpha NE2 Neighboring gene uncharacterized protein Neighboring gene jdp

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Fork head and Sage maintain a uniform and patent salivary gland lumen through regulation of two downstream target genes, PH4alphaSG1 and PH4alphaSG2. Abrams EW, et al. Development, 2006 Sep. PMID 16914497
    2. Cold acclimation wholly reorganizes the Drosophila melanogaster transcriptome and metabolome. MacMillan HA, et al. Sci Rep, 2016 Jun 30. PMID 27357258, Free PMC Article
    3. Transcriptomic analysis of inbreeding depression in cold-sensitive Drosophila melanogaster shows upregulation of the immune response. Vermeulen CJ, et al. J Evol Biol, 2013 Sep. PMID 23944235
    4. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article
    5. A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene. Neely GG, et al. Cell, 2010 Nov 12. PMID 21074052, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables L-ascorbic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables procollagen-proline 4-dioxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables procollagen-proline 4-dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG31524-PA
    CG31524-PB
    NP_001036777.1
    NP_733379.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      30512325..30514355 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001043312.2 → NP_001036777.1  uncharacterized protein Dmel_CG31524, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036777.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0KHY6, Q4V5K4
      Conserved Domains (4) summary
      smart00702
      Location:339 → 506
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam07719
      Location:215 → 248
      TPR_2; Tetratricopeptide repeat
      pfam08336
      Location:31 → 156
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region
      pfam13414
      Location:214 → 258
      TPR_11; TPR repeat

    2. NM_170500.3 → NP_733379.2  uncharacterized protein Dmel_CG31524, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733379.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      C9QPA9, Q8IMI2
      Conserved Domains (4) summary
      smart00702
      Location:340 → 507
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam07719
      Location:216 → 249
      TPR_2; Tetratricopeptide repeat
      pfam08336
      Location:31 → 157
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region
      pfam13414
      Location:215 → 259
      TPR_11; TPR repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0KHY6 Q0KHY6
    Q8IMI2 Q8IMI2

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