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    nrm neuromusculin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40515, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nrmprovided by FlyBase
    Official Full Name
    neuromusculinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0262509
    Locus tag
    Dmel_CG43079
    See related
    AllianceGenome:FB:FBgn0262509
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG32458; CG41452; CG43079; CG8779; CT16082; Dmel\CG43079
    Old locus tag
    Dmel_CG32458; Dmel_CG41452; Dmel_CG8779
    Summary
    Involved in synaptic target recognition. Located in plasma membrane. Is expressed in several structures, including adult somatic muscle cell; imaginal disc; muscle system; neurogenic region; and sense organ. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See nrm in Genome Data Viewer
    Location:
    80C2-80C4; 3-47 cM
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (22998372..23040300)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (22991472..23033400)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45758 Neighboring gene uncharacterized protein Neighboring gene casein kinase IIalpha Neighboring gene Ribosomal protein L10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Neural enhancer-like elements as specific cell markers in Drosophila. Ghysen A, et al. Development, 1989 Jan. PMID 2509189
    2. numb, a gene required in determination of cell fate during sensory organ formation in Drosophila embryos. Uemura T, et al. Cell, 1989 Jul 28. PMID 2752427
    3. Mutations in neuromusculin, a gene encoding a cell adhesion molecule, cause nervous system defects. Kania A, et al. Rouxs Arch Dev Biol, 1995 Mar. PMID 28306121
    4. The development of normal and ectopic sensilla in the wings of hairy and Hairy wing mutants of Drosophila. Blair SS, et al. Mech Dev, 1992 Jul. PMID 1381943
    5. Neuromusculin, a Drosophila gene expressed in peripheral neuronal precursors and muscles, encodes a cell adhesion molecule. Kania A, et al. Neuron, 1993 Oct. PMID 8398154

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 22999734-23000135 mobile_element_type = transposon:INE-1{}3189
    • Loc: 23003670-23003771 mobile_element_type = transposon:INE-1{}3193
    • Loc: 23004182-23004312 mobile_element_type = transposon:INE-1{}3989
    • Loc: 23004700-23004842 mobile_element_type = transposon:INE-1{}3196
    • Loc: 23006313-23006847 mobile_element_type = transposon:INE-1{}3211
    • Loc: 23008290-23008406 mobile_element_type = transposon:hopper2{}3299
    • Loc: 23008600-23008913 mobile_element_type = transposon:INE-1{}3212
    • Loc: 23018033-23018300 mobile_element_type = transposon:INE-1{}3213
    • Loc: 23021443-23021574 mobile_element_type = transposon:INE-1{}3214
    • Loc: 23022458-23023339 mobile_element_type = transposon:INE-1{}3215
    • Loc: 23023576-23023803 mobile_element_type = transposon:INE-1{}3220
    • Loc: 23027806-23029190 mobile_element_type = transposon:Cr1a{}1596
    • Loc: 23036067-23036402 mobile_element_type = transposon:INE-1{}3227
    • Loc: 23039222-23039688 mobile_element_type = transposon:G5A{}3260

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in synaptic target recognition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    neuromusculin
    Names
    CG43079-PA
    CG43079-PB
    CG43079-PE
    CG43079-PF
    CG43079-PH
    CG43079-PI
    nrm-PA
    nrm-PB
    nrm-PE
    nrm-PF
    nrm-PH
    nrm-PI

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      22998372..23040300
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275303.1 → NP_001262232.1  neuromusculin, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262232.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PGA2
      Conserved Domains (4) summary
      cd00096
      Location:394 → 463
      Ig; Immunoglobulin domain
      smart00410
      Location:383 → 463
      IG_like; Immunoglobulin like
      pfam13927
      Location:585 → 652
      Ig_3; Immunoglobulin domain
      cl11960
      Location:176 → 248
      Ig; Immunoglobulin domain

    2. NM_001259964.2 → NP_001246893.1  neuromusculin, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246893.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D2NUE2, M9NGD9
      Conserved Domains (3) summary
      cd00096
      Location:394 → 463
      Ig; Immunoglobulin domain
      smart00410
      Location:383 → 463
      IG_like; Immunoglobulin like
      cl11960
      Location:176 → 248
      Ig; Immunoglobulin domain

    3. NM_001259962.2 → NP_001246891.1  neuromusculin, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246891.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D2NUE2, M9NEJ8
      Conserved Domains (4) summary
      cd00096
      Location:394 → 463
      Ig; Immunoglobulin domain
      smart00410
      Location:383 → 463
      IG_like; Immunoglobulin like
      pfam13927
      Location:585 → 652
      Ig_3; Immunoglobulin domain
      cl11960
      Location:176 → 248
      Ig; Immunoglobulin domain

    4. NM_001259961.2 → NP_001246890.1  neuromusculin, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246890.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NE05
      Conserved Domains (4) summary
      cd00096
      Location:394 → 463
      Ig; Immunoglobulin domain
      smart00410
      Location:383 → 463
      IG_like; Immunoglobulin like
      pfam13927
      Location:585 → 652
      Ig_3; Immunoglobulin domain
      cl11960
      Location:176 → 248
      Ig; Immunoglobulin domain

    5. NM_001043156.3 → NP_001036621.1  neuromusculin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036621.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E8B8, Q24273
      Conserved Domains (4) summary
      cd00096
      Location:394 → 463
      Ig; Immunoglobulin domain
      smart00410
      Location:383 → 463
      IG_like; Immunoglobulin like
      pfam13927
      Location:585 → 652
      Ig_3; Immunoglobulin domain
      cl11960
      Location:176 → 248
      Ig; Immunoglobulin domain

    6. NM_079494.5 → NP_524218.4  neuromusculin, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524218.4

      Status: REVIEWED

      UniProtKB/TrEMBL
      D2NUE2, Q9VNP2
      Conserved Domains (4) summary
      cd00096
      Location:394 → 463
      Ig; Immunoglobulin domain
      smart00410
      Location:383 → 463
      IG_like; Immunoglobulin like
      pfam13927
      Location:585 → 652
      Ig_3; Immunoglobulin domain
      cl11960
      Location:176 → 248
      Ig; Immunoglobulin domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9NE05 M9NE05
    M9NEJ8 M9NEJ8
    M9NGD9 M9NGD9
    M9PGA2 M9PGA2
    Q0E8B8 Q0E8B8
    Q24273 Q24273
    Q9VNP2 Q9VNP2

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