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    kek4 kekkon 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34718, updated on 9-Dec-2024

    Summary

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    Official Symbol
    kek4provided by FlyBase
    Official Full Name
    kekkon 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0032484
    Locus tag
    Dmel_CG9431
    See related
    AllianceGenome:FB:FBgn0032484
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9431; CT26742; Dmel\CG9431; kek-4
    Summary
    Predicted to be located in plasma membrane. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 64 and glaucoma. Orthologous to human LINGO1 (leucine rich repeat and Ig domain containing 1) and LINGO2 (leucine rich repeat and Ig domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See kek4 in Genome Data Viewer
    Location:
    34A9-34A10; 2-47 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (13212335..13215350, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (13212335..13215350, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Phosphoethanolamine cytidylyltransferase Neighboring gene small nuclear RNA U2 at 34AB a Neighboring gene uncharacterized protein Neighboring gene small nuclear RNA U2 at 34AB b Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Conservation of an inhibitor of the epidermal growth factor receptor, Kekkon1, in dipterans. Derheimer FA, et al. Genetics, 2004 Jan. PMID 15020419, Free PMC Article
    2. Comparative analysis of the Kekkon molecules, related members of the LIG superfamily. MacLaren CM, et al. Dev Genes Evol, 2004 Jul. PMID 15179511
    3. Bipartite inhibition of Drosophila epidermal growth factor receptor by the extracellular and transmembrane domains of Kekkon1. Alvarado D, et al. Genetics, 2004 May. PMID 15166146, Free PMC Article
    4. Kekkon5 is an extracellular regulator of BMP signaling. Evans TA, et al. Dev Biol, 2009 Feb 1. PMID 19013143
    5. Kek-6: A truncated-Trk-like receptor for Drosophila neurotrophin 2 regulates structural synaptic plasticity. Ulian-Benitez S, et al. PLoS Genet, 2017 Aug. PMID 28846707, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Component Evidence Code Pubs
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    kekkon 4
    Names
    CG9431-PA
    CG9431-PB
    CG9431-PC
    kek4-PA
    kek4-PB
    kek4-PC
    kekkon-like
    kekkon4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      13212335..13215350 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273507.1 → NP_001260436.1  kekkon 4, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260436.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VK22
      Conserved Domains (5) summary
      cd00096
      Location:296 → 387
      Ig; Immunoglobulin domain
      smart00410
      Location:294 → 390
      IG_like; Immunoglobulin like
      sd00033
      Location:75 → 99
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:99 → 158
      LRR_8; Leucine rich repeat
      cl15307
      Location:228 → 277
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    2. NM_001273506.1 → NP_001260435.1  kekkon 4, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260435.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VK22
      Conserved Domains (5) summary
      cd00096
      Location:296 → 387
      Ig; Immunoglobulin domain
      smart00410
      Location:294 → 390
      IG_like; Immunoglobulin like
      sd00033
      Location:75 → 99
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:99 → 158
      LRR_8; Leucine rich repeat
      cl15307
      Location:228 → 277
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    3. NM_135771.2 → NP_609615.2  kekkon 4, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609615.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VK22
      Related
      FBpp0080064, FBtr0080485
      Conserved Domains (5) summary
      cd00096
      Location:296 → 387
      Ig; Immunoglobulin domain
      smart00410
      Location:294 → 390
      IG_like; Immunoglobulin like
      sd00033
      Location:75 → 99
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:99 → 158
      LRR_8; Leucine rich repeat
      cl15307
      Location:228 → 277
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8T0J0 Q8T0J0
    Q9VK22 Q9VK22

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