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    rngo rings lost [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32616, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rngoprovided by FlyBase
    Official Full Name
    rings lostprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030753
    Locus tag
    Dmel_CG4420
    See related
    AllianceGenome:FB:FBgn0030753
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4420; Ddi1; Dmel\CG4420; Rngo
    Summary
    Enables proteasome binding activity and ubiquitin binding activity. Involved in female germline ring canal formation. Located in cytoplasm and nucleus. Is expressed in several structures, including CNS glial cell; embryonic/larval midgut primordium; ganglia; head epidermis primordium; and mesoderm. Orthologous to human DDI1 (DNA damage inducible 1 homolog 1) and DDI2 (DNA damage inducible 1 homolog 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See rngo in Genome Data Viewer
    Location:
    14C6-14C6; 1-53 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (16441433..16445367)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16335466..16339400)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene hangover Neighboring gene Cell division cycle 50 Neighboring gene eukaryotic translation initiation factor 2 subunit alpha Neighboring gene uncharacterized protein Neighboring gene eukaryotic translation initiation factor 4H1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Non-Proteasomal UbL-UbA Family of Proteins in Neurodegeneration. Jantrapirom S, et al. Int J Mol Sci, 2019 Apr 17. PMID 30999567, Free PMC Article
    2. Quantitative proteomics reveals neuronal ubiquitination of Rngo/Ddi1 and several proteasomal subunits by Ube3a, accounting for the complexity of Angelman syndrome. Ramirez J, et al. Hum Mol Genet, 2018 Jun 1. PMID 29788202
    3. Loss of the extraproteasomal ubiquitin receptor Rings lost impairs ring canal growth in Drosophila oogenesis. Morawe T, et al. J Cell Biol, 2011 Apr 4. PMID 21444692, Free PMC Article
    4. Developmental-stage-specific regulation of the polyubiquitin receptors in Drosophila melanogaster. Lipinszki Z, et al. J Cell Sci, 2009 Sep 1. PMID 19654212
    5. USP5/Leon deubiquitinase confines postsynaptic growth by maintaining ubiquitin homeostasis through Ubiquilin. Wang CH, et al. Elife, 2017 May 10. PMID 28489002, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables aspartic-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables proteasome binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in female germline ring canal formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rings lost
    Names
    CG4420-PA
    CG4420-PB
    rngo-PA
    rngo-PB
    NP_001285328.1
    NP_573129.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      16441433..16445367
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132901.3 → NP_573129.1  rings lost, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573129.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VXF9
      Related
      FBpp0074054
      Conserved Domains (4) summary
      cd05479
      Location:225 → 344
      RP_DDI; RP_DDI; retropepsin-like domain of DNA damage inducible protein
      cd01796
      Location:3 → 72
      DDI1_N; DNA damage inducible protein 1 ubiquitin-like domain
      smart00213
      Location:1 → 73
      UBQ; Ubiquitin homologues
      pfam00627
      Location:411 → 445
      UBA; UBA/TS-N domain

    2. NM_001298399.1 → NP_001285328.1  rings lost, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285328.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VXF9
      Conserved Domains (4) summary
      cd05479
      Location:225 → 344
      RP_DDI; RP_DDI; retropepsin-like domain of DNA damage inducible protein
      cd01796
      Location:3 → 72
      DDI1_N; DNA damage inducible protein 1 ubiquitin-like domain
      smart00213
      Location:1 → 73
      UBQ; Ubiquitin homologues
      pfam00627
      Location:411 → 445
      UBA; UBA/TS-N domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VXF9 Q9VXF9

    Gene LinkOut

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