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    Arpc3A Actin-related protein 2/3 complex, subunit 3A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41917, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Arpc3Aprovided by FlyBase
    Official Full Name
    Actin-related protein 2/3 complex, subunit 3Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038369
    Locus tag
    Dmel_CG4560
    See related
    AllianceGenome:FB:FBgn0038369
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ARC-P21; ARPC; Arpc3; Arpc3a; CG4560; Dmel\CG4560
    Summary
    Predicted to be a structural constituent of cytoskeleton. Predicted to contribute to actin filament binding activity. Predicted to be involved in Arp2/3 complex-mediated actin nucleation. Predicted to be located in cytoskeleton. Predicted to be part of Arp2/3 protein complex. Is expressed in adult head. Orthologous to human ARPC3 (actin related protein 2/3 complex subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Arpc3A in Genome Data Viewer
    Location:
    89A5-89A5; 3-58 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15834648..15836021)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11660370..11661743)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene mir-4911 stem loop Neighboring gene NADH dehydrogenase (ubiquinone) 23 kDa subunit Neighboring gene spindle E Neighboring gene PSEA-binding protein 45kD

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RNAi screen in the Drosophila wing of genes encoding proteins related to cytoskeleton organization and cell division. Ostalé CM, et al. Dev Biol, 2023 Jun. PMID 37015290
    2. The temporally controlled expression of Drongo, the fruit fly homolog of AGFG1, is achieved in female germline cells via P-bodies and its localization requires functional Rab11. Catrina IE, et al. RNA Biol, 2016 Nov. PMID 27654348, Free PMC Article
    3. A subset of dynamic actin rearrangements in Drosophila requires the Arp2/3 complex. Hudson AM, et al. J Cell Biol, 2002 Feb 18. PMID 11854308, Free PMC Article
    4. Arp2/3-dependent mechanical control of morphogenetic robustness in an inherently challenging environment. Martin E, et al. Dev Cell, 2021 Mar 8. PMID 33535069, Free PMC Article
    5. The diaphanous gene of Drosophila interacts antagonistically with multiple wing hairs and plays a key role in wing hair morphogenesis. Lu Q, et al. PLoS One, 2015. PMID 25730111, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    contributes_to actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of cytoskeleton ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Arp2/3 complex-mediated actin nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Arp2/3 complex-mediated actin nucleation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in Arp2/3 complex-mediated actin nucleation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in regulation of actin filament polymerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Arp2/3 protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Arp2/3 protein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of Arp2/3 protein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Actin-related protein 2/3 complex, subunit 3A
    Names
    Arpc3A-PC
    Arpc3A-PE
    CG4560-PC
    CG4560-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      15834648..15836021
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169675.3 → NP_732075.3  Actin-related protein 2/3 complex, subunit 3A, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732075.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0C4FEI6, Q29QX5, Q8IND1, Q9VF28
      Conserved Domains (1) summary
      pfam04062
      Location:1 → 172
      P21-Arc; ARP2/3 complex ARPC3 (21 kDa) subunit

    2. NM_142241.2 → NP_650498.3  Actin-related protein 2/3 complex, subunit 3A, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650498.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0C4FEI6, Q29QX5, Q8IND1, Q9VF28
      Conserved Domains (1) summary
      pfam04062
      Location:1 → 172
      P21-Arc; ARP2/3 complex ARPC3 (21 kDa) subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VF28 Q9VF28

    Gene LinkOut

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