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    Prp40 pre-mRNA processing factor 40 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33513, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Prp40provided by FlyBase
    Official Full Name
    pre-mRNA processing factor 40provided by FlyBase
    Primary source
    FLYBASE:FBgn0031492
    Locus tag
    Dmel_CG3542
    See related
    AllianceGenome:FB:FBgn0031492
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3542; Dmel\CG3542; dPrp40; prp40
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Located in histone locus body. Part of precatalytic spliceosome. Is expressed in several structures, including antennal primordium; central brain primordium; embryonic/larval midgut primordium; ganglia; and head epidermis primordium. Orthologous to several human genes including PRPF40B (pre-mRNA processing factor 40 homolog B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Prp40 in Genome Data Viewer
    Location:
    23C4-23C4; 2-8 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (3023226..3026439)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (3023226..3026439)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene alpha1,4-galactosyltransferase 1 Neighboring gene Splicing factor 3b subunit 2 Neighboring gene antisense RNA:CR44147 Neighboring gene uncharacterized protein Neighboring gene beta4GalNAcTB pilot Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila Prp40 localizes to the histone locus body and regulates gene transcription and development. Prieto-Sánchez S, et al. J Cell Sci, 2020 Apr 7. PMID 32094262
    2. A Pair of Oviduct-Born Pickpocket Neurons Important for Egg-Laying in Drosophila melanogaster. Lee H, et al. Mol Cells, 2016 Jul. PMID 27378227, Free PMC Article
    3. The regulation of glial-specific splicing of Neurexin IV requires HOW and Cdk12 activity. Rodrigues F, et al. Development, 2012 May. PMID 22461565
    4. Notch ligand activity is modulated by glycosphingolipid membrane composition in Drosophila melanogaster. Hamel S, et al. J Cell Biol, 2010 Feb 22. PMID 20176925, Free PMC Article
    5. Evidence for large domains of similarly expressed genes in the Drosophila genome. Spellman PT, et al. J Biol, 2002. PMID 12144710, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA cis splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of U1 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U1 snRNP ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of U2-type prespliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in histone locus body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of precatalytic spliceosome HDA PubMed 

    General protein information

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    Preferred Names
    pre-mRNA processing factor 40
    Names
    CG3542-PA
    Prp40-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      3023226..3026439
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_134894.4 → NP_608738.1  pre-mRNA processing factor 40 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608738.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VQK5, Q9VQK6
      Related
      FBpp0077333
      Conserved Domains (3) summary
      COG5104
      Location:54 → 634
      PRP40; Splicing factor [RNA processing and modification]
      pfam00397
      Location:54 → 81
      WW; WW domain
      pfam01846
      Location:231 → 280
      FF; FF domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VQK5 Q9VQK5

    Gene LinkOut

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