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    eIF3g1 eukaryotic translation initiation factor 3 subunit g1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31243, updated on 9-Dec-2024

    Summary

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    Official Symbol
    eIF3g1provided by FlyBase
    Official Full Name
    eukaryotic translation initiation factor 3 subunit g1provided by FlyBase
    Primary source
    FLYBASE:FBgn0029629
    Locus tag
    Dmel_CG8636
    See related
    AllianceGenome:FB:FBgn0029629
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg8636; CG8636; Dmel\CG8636; eIF s4; eIF-3; eIF-3ga; eIF3-S4; eIF3g; eIF3G1; eIF3ga
    Summary
    Predicted to enable mRNA binding activity and translation initiation factor activity. Involved in mitotic cell cycle. Predicted to be located in cytoplasm. Predicted to be part of eukaryotic translation initiation factor 3 complex. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; gut section; larval muscle cell; and mesoderm. Orthologous to human EIF3G (eukaryotic translation initiation factor 3 subunit G). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See eIF3g1 in Genome Data Viewer
    Location:
    3A7-3A7; 1-1 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2609247..2610336, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (2503280..2504369, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Kinesin-like protein at 3A Neighboring gene Zeste-white 10 Neighboring gene SET and MYND domain containing, class 3 Neighboring gene Tetraspanin 3A Neighboring gene seipin Neighboring gene brivido-3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dissecting the roles of EIF4G homologs reveals DAP5 as a modifier of CGG repeat-associated toxicity in a Drosophila model of FXTAS. Malik I, et al. Neurobiol Dis, 2023 Aug. PMID 37352983, Free PMC Article
    2. Identification of Novel Regulators of the JAK/STAT Signaling Pathway that Control Border Cell Migration in the Drosophila Ovary. Saadin A, et al. G3 (Bethesda), 2016 Jul 7. PMID 27175018, Free PMC Article
    3. A TORC1-histone axis regulates chromatin organisation and non-canonical induction of autophagy to ameliorate ageing. Lu YX, et al. Elife, 2021 May 14. PMID 33988501, Free PMC Article
    4. SRSF protein kinase 1 modulates RAN translation and suppresses CGG repeat toxicity. Malik I, et al. EMBO Mol Med, 2021 Nov 8. PMID 34542927, Free PMC Article
    5. Phenotypic suppression of the Drosophila mitochondrial disease-like mutant tko(25t) by duplication of the mutant gene in its natural chromosomal context. Kemppainen E, et al. Mitochondrion, 2009 Sep. PMID 19616644

    See all (68) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation initiation factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitotic cell cycle HMP PubMed 
    involved_in translational initiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic translation initiation factor 3 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic translation initiation factor 3 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 3 subunit g1
    Names
    CG8636-PA
    eIF3g paralogue a
    eIF3g1-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      2609247..2610336 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_130655.2 → NP_570011.1  eukaryotic translation initiation factor 3 subunit g1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_570011.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W4X7
      Related
      FBpp0070430
      Conserved Domains (3) summary
      COG0724
      Location:161 → 269
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12408
      Location:189 → 265
      RRM_eIF3G_like; RNA recognition motif in eukaryotic translation initiation factor 3 subunit G (eIF-3G) and similar proteins
      pfam12353
      Location:30 → 140
      eIF3g; Eukaryotic translation initiation factor 3 subunit G
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W4X7.1 Q9W4X7

    Gene LinkOut

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