U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Pcf11 Pcf11 cleavage and polyadenylation factor subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36658, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Pcf11provided by FlyBase
    Official Full Name
    Pcf11 cleavage and polyadenylation factor subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0264962
    Locus tag
    Dmel_CG10228
    See related
    AllianceGenome:FB:FBgn0264962
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.146; CG10228; Dmel\CG10228; dPcf11; Inr-a; l(2)k08015; pcf11; PCF11
    Summary
    Enables RNA binding activity. Predicted to be involved in termination of RNA polymerase II transcription. Predicted to be part of mRNA cleavage factor complex. Predicted to be active in cytoplasm. Is expressed in spermatozoon. Orthologous to human PCF11 (PCF11 cleavage and polyadenylation factor subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Pcf11 in Genome Data Viewer
    Location:
    51C5-51C7; 2-72 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (14860936..14871071, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (10748441..10758576, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Hermansky-Pudlak Syndrome 1 Neighboring gene uncharacterized protein Neighboring gene U3 small nuclear riboprotein factor 55K Neighboring gene Cytochrome P450 6a22 Neighboring gene Cytochrome P450 6a17

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Identification of Inverse Regulator-a (Inr-a) as Synonymous with Pre-mRNA Cleavage Complex II Protein (Pcf11) in Drosophila. Xie W, et al. G3 (Bethesda), 2012 Jun. PMID 22690379, Free PMC Article
    2. A trans-acting regulatory gene that inversely affects the expression of the white, brown and scarlet loci in Drosophila. Rabinow L, et al. Genetics, 1991 Oct. PMID 1743487, Free PMC Article
    3. Role of multiple trans-acting regulators in modifying the effect of the retrotransposon copia on host gene expression in Drosophila. Pal Bhadra M, et al. Mol Gen Genet, 1998 Aug. PMID 9747711
    4. A developmental mechanism to regulate alternative polyadenylation in an adult stem cell lineage. Gallicchio L, et al. Genes Dev, 2024 Aug 20. PMID 39111825,
    5. Interactions among dosage-dependent trans-acting modifiers of gene expression and position-effect variegation in Drosophila. Bhadra U, et al. Genetics, 1998 Sep. PMID 9725844, Free PMC Article

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Modulation of Global Gene Expression by Aneuploidy and CNV of Dosage Sensitive Regulatory Genes.
      Title: Modulation of Global Gene Expression by Aneuploidy and CNV of Dosage Sensitive Regulatory Genes.
    2. Data show that Pcf11 is directly involved in transcription termination in Drosophila.
      Title: Pcf11 is a termination factor in Drosophila that dismantles the elongation complex by bridging the CTD of RNA polymerase II to the nascent transcript.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II complex binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA 3'-end processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in termination of RNA polymerase II transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in termination of RNA polymerase II transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mRNA cleavage factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Pcf11 cleavage and polyadenylation factor subunit
    Names
    CG10228-PB
    CG10228-PC
    CG10228-PD
    CG10228-PE
    CG10228-PF
    CG10228-PG
    CG10228-PH
    Pcf11-PB
    Pcf11-PC
    Pcf11-PD
    Pcf11-PE
    Pcf11-PF
    Pcf11-PG
    Pcf11-PH
    inverse regulator a
    lethal (2) k08015
    protein 1 of cleavage and polyadenylation factor 1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      14860936..14871071 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299501.1 → NP_001286430.1  Pcf11 cleavage and polyadenylation factor subunit, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286430.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LFF9
      Conserved Domains (3) summary
      cd03562
      Location:17 → 134
      CID; CID (CTD-Interacting Domain) domain family; CID is present in several RNA-processing factors such as Pcf11 and Nrd1. Pcf11 is a conserved and essential subunit of the yeast cleavage factor IA, which is required for polyadenylation-dependent 3'-RNA ...
      pfam00836
      Location:622 → 725
      Stathmin; Stathmin family
      pfam09032
      Location:187 → 255
      Siah-Interact_N; Siah interacting protein, N terminal

    2. NM_001202002.2 → NP_001188931.1  Pcf11 cleavage and polyadenylation factor subunit, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188931.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LFF9
      Conserved Domains (3) summary
      cd03562
      Location:17 → 134
      CID; CID (CTD-Interacting Domain) domain family; CID is present in several RNA-processing factors such as Pcf11 and Nrd1. Pcf11 is a conserved and essential subunit of the yeast cleavage factor IA, which is required for polyadenylation-dependent 3'-RNA ...
      pfam00836
      Location:622 → 725
      Stathmin; Stathmin family
      pfam09032
      Location:187 → 255
      Siah-Interact_N; Siah interacting protein, N terminal

    3. NM_001299499.1 → NP_001286428.1  Pcf11 cleavage and polyadenylation factor subunit, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286428.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LF47
      Conserved Domains (3) summary
      cd03562
      Location:17 → 134
      CID; CID (CTD-Interacting Domain) domain family; CID is present in several RNA-processing factors such as Pcf11 and Nrd1. Pcf11 is a conserved and essential subunit of the yeast cleavage factor IA, which is required for polyadenylation-dependent 3'-RNA ...
      pfam00836
      Location:633 → 736
      Stathmin; Stathmin family
      pfam09032
      Location:187 → 255
      Siah-Interact_N; Siah interacting protein, N terminal

    4. NM_001299500.1 → NP_001286429.1  Pcf11 cleavage and polyadenylation factor subunit, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286429.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LFE6
      Conserved Domains (3) summary
      cd03562
      Location:17 → 134
      CID; CID (CTD-Interacting Domain) domain family; CID is present in several RNA-processing factors such as Pcf11 and Nrd1. Pcf11 is a conserved and essential subunit of the yeast cleavage factor IA, which is required for polyadenylation-dependent 3'-RNA ...
      pfam00836
      Location:728 → 831
      Stathmin; Stathmin family
      pfam09032
      Location:187 → 255
      Siah-Interact_N; Siah interacting protein, N terminal

    5. NM_137155.5 → NP_610999.4  Pcf11 cleavage and polyadenylation factor subunit, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610999.4

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z9W4, C6SUY2
      Conserved Domains (3) summary
      cd03562
      Location:17 → 134
      CID; CID (CTD-Interacting Domain) domain family; CID is present in several RNA-processing factors such as Pcf11 and Nrd1. Pcf11 is a conserved and essential subunit of the yeast cleavage factor IA, which is required for polyadenylation-dependent 3'-RNA ...
      pfam00836
      Location:736 → 839
      Stathmin; Stathmin family
      pfam09032
      Location:187 → 255
      Siah-Interact_N; Siah interacting protein, N terminal

    6. NM_001169682.2 → NP_001163153.1  Pcf11 cleavage and polyadenylation factor subunit, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163153.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JH68, Q8IGR2
      Conserved Domains (2) summary
      cd03562
      Location:17 → 134
      CID; CID (CTD-Interacting Domain) domain family; CID is present in several RNA-processing factors such as Pcf11 and Nrd1. Pcf11 is a conserved and essential subunit of the yeast cleavage factor IA, which is required for polyadenylation-dependent 3'-RNA ...
      pfam09032
      Location:187 → 255
      Siah-Interact_N; Siah interacting protein, N terminal

    7. NM_001169683.2 → NP_001163154.1  Pcf11 cleavage and polyadenylation factor subunit, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163154.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C0P8M6
      Conserved Domains (1) summary
      cl02544
      Location:17 → 62
      VHS_ENTH_ANTH; VHS, ENTH and ANTH domain superfamily; composed of proteins containing a VHS, ENTH or ANTH domain. The VHS domain is present in Vps27 (Vacuolar Protein Sorting), Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) and STAM (Signal ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LF47 A0A0B4LF47
    A0A0B4LFE6 A0A0B4LFE6
    A0A0B4LFF9 A0A0B4LFF9
    A1Z9W4 A1Z9W4
    C0P8M6 C0P8M6
    E1JH68 E1JH68
    Q8IGR2 Q8IGR2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous