lsn larsen [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: lsnprovided by FlyBase
Official Full Name: larsenprovided by FlyBase
Primary source: FLYBASE:FBgn0260940
Locus tag: Dmel_CG6637
See related: AllianceGenome:FB:FBgn0260940
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG6637; Dmel\CG6637; Lsn; vps22; Vps22
Summary: Involved in several processes, including bicoid mRNA localization; multivesicular body assembly; and ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway. Predicted to be part of ESCRT II complex. Used to study cancer. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy. Orthologous to human SNF8 (SNF8 subunit of ESCRT-II). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (21865168..21866238)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (17690890..17691960)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in bicoid mRNA localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endosome transport via multivesicular body sorting pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multivesicular body assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multivesicular body sorting pathway	IEA Inferred from Electronic Annotation more info
involved_in protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of ESCRT II complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ESCRT II complex	IEA Inferred from Electronic Annotation more info
part_of ESCRT II complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed