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    PpD6 Protein phosphatase D6 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 49780, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PpD6provided by FlyBase
    Official Full Name
    Protein phosphatase D6provided by FlyBase
    Primary source
    FLYBASE:FBgn0005779
    Locus tag
    Dmel_CG8822
    See related
    AllianceGenome:FB:FBgn0005779
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8822; D6; Dmel\CG8822; PP1; PPD6
    Summary
    Predicted to enable protein serine/threonine phosphatase activity. Predicted to be active in cytoplasm and nucleus. Is expressed in elongation stage spermatid; organism; and testis. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See PpD6 in Genome Data Viewer
    Location:
    23D1-23D1; 2-8 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (3109672..3110998)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (3109672..3110998)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene small nuclear RNA U5 at 23D Neighboring gene Fatty acid synthase 2 Neighboring gene Fatty acid synthase 1 Neighboring gene toucan Neighboring gene uncharacterized protein Neighboring gene NADH dehydrogenase (ubiquinone) B14.5 B subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of phosphatases for Smad in the BMP/DPP pathway. Chen HB, et al. Genes Dev, 2006 Mar 15. PMID 16510868, Free PMC Article
    2. A phosphoswitch at acinus-serine(437) controls autophagic responses to cadmium exposure and neurodegenerative stress. Nandi N, et al. Elife, 2022 Jan 17. PMID 35037620, Free PMC Article
    3. Polymerase chain reactions using Saccharomyces, Drosophila and human DNA predict a large family of protein serine/threonine phosphatases. Chen MX, et al. FEBS Lett, 1992 Jul 13. PMID 1321058
    4. SUR-8 interacts with PP1-87B to stabilize PERIOD and regulate circadian rhythms in Drosophila. Xue Y, et al. PLoS Genet, 2019 Nov. PMID 31710605, Free PMC Article
    5. An RNAi Screen To Identify Protein Phosphatases That Function Within the Drosophila Circadian Clock. Agrawal P, et al. G3 (Bethesda), 2016 Dec 7. PMID 27784754, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein phosphatase D6
    Names
    CG8822-PA
    PP1-like
    PpD6-PA
    protein phosphatase from PCR fragment D6
    NP_524947.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      3109672..3110998
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080208.3 → NP_524947.1  protein phosphatase D6 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524947.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q26246, Q6NNT3, Q9VQL9
      Related
      FBpp0077344
      Conserved Domains (2) summary
      smart00156
      Location:54 → 315
      PP2Ac; Protein phosphatase 2A homologues, catalytic domain
      cl13995
      Location:51 → 317
      MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JPT9 Q7JPT9
    Q9VQL9 Q9VQL9

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