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    ND-B8 NADH dehydrogenase (ubiquinone) B8 subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 50178, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ND-B8provided by FlyBase
    Official Full Name
    NADH dehydrogenase (ubiquinone) B8 subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0040705
    Locus tag
    Dmel_CG15434
    See related
    AllianceGenome:FB:FBgn0040705
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG15434; Dmel\CG15434; dNDUFA2; NDUFA2; NI8M
    Summary
    Predicted to be involved in mitochondrial respiratory chain complex I assembly. Predicted to be part of respiratory chain complex I. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 13. Orthologous to human NDUFA2 (NADH:ubiquinone oxidoreductase subunit A2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ND-B8 in Genome Data Viewer
    Location:
    24F3-24F3; 2-12 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (4454626..4455207)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (4454626..4455207)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene tRNA Selenocysteine associated protein Neighboring gene GS1-like Neighboring gene ncRNA Neighboring gene Ribosomal protein L27A Neighboring gene mitochondrial ribosomal protein L27

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcriptome analysis of a long-lived natural Drosophila variant: a prominent role of stress- and reproduction-genes in lifespan extension. Doroszuk A, et al. BMC Genomics, 2012 May 4. PMID 22559237, Free PMC Article
    2. Identification of a mitochondrial target of thiazolidinedione insulin sensitizers (mTOT)--relationship to newly identified mitochondrial pyruvate carrier proteins. Colca JR, et al. PLoS One, 2013. PMID 23690925, Free PMC Article
    3. Phenotypic plasticity and genotype by environment interaction for olfactory behavior in Drosophila melanogaster. Sambandan D, et al. Genetics, 2008 Jun. PMID 18505870, Free PMC Article
    4. Resting mitochondrial complex I from Drosophila melanogaster adopts a helix-locked state. Padavannil A, et al. Elife, 2023 Mar 23. PMID 36952377, Free PMC Article
    5. Mitochondrial dysfunction reveals the role of mRNA poly(A) tail regulation in oculopharyngeal muscular dystrophy pathogenesis. Chartier A, et al. PLoS Genet, 2015 Mar. PMID 25816335, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in mitochondrial respiratory chain complex I assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of respiratory chain complex I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex I ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    NADH dehydrogenase (ubiquinone) B8 subunit
    Names
    CG15434-PA
    NADH ubiquinone oxidoreductase B8
    NADH-ubiquinone oxidoreductase B8 subunit
    NADH:ubiquinone oxidoreductase B8 subunit
    ND-B8-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      4454626..4455207
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_144084.3 → NP_652341.1  NADH dehydrogenase (ubiquinone) B8 subunit [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652341.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VR00
      Related
      FBpp0077130
      Conserved Domains (1) summary
      smart00916
      Location:29 → 93
      L51_S25_CI-B8; Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VR00 Q9VR00

    Gene LinkOut

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