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    eIF3e eukaryotic translation initiation factor 3 subunit e [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39877, updated on 9-Dec-2024

    Summary

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    Official Symbol
    eIF3eprovided by FlyBase
    Official Full Name
    eukaryotic translation initiation factor 3 subunit eprovided by FlyBase
    Primary source
    FLYBASE:FBgn0025582
    Locus tag
    Dmel_CG9677
    See related
    AllianceGenome:FB:FBgn0025582
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA.GM01233; BcDNA:GM01233; CG9677; DINT6; Dmel\CG9677; eIF-3p48/INT-6; eIF3-p48/INT6; eIF3-S6; Int6; l(3)10547; l(3)j9E8
    Summary
    Predicted to enable translation initiation factor activity. Predicted to be involved in translational initiation. Located in intracellular membrane-bounded organelle. Is expressed in several structures, including adult head; adult heart; embryonic/larval midgut primordium; ganglia; and mesoderm. Orthologous to human EIF3E (eukaryotic translation initiation factor 3 subunit E). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See eIF3e in Genome Data Viewer
    Location:
    73C4-73C4; 3-44 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16785242..16786941, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16778342..16780041, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Neurotactin Neighboring gene mutagen-sensitive 302 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene nudC Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of the Drosophila ortholog of mouse eIF-3p48/INT-6. Miyazaki S, et al. Gene, 1999 Jun 11. PMID 10375641
    2. The Drosophila orthologue of the INT6 onco-protein regulates mitotic microtubule growth and kinetochore structure. Renda F, et al. PLoS Genet, 2017 May. PMID 28505193, Free PMC Article
    3. Characterization of DnudC, the Drosophila homolog of an Aspergillus gene that functions in nuclear motility. Cunniff J, et al. Mech Dev, 1997 Aug. PMID 9376324
    4. The proto-oncogene Int6 is essential for neddylation of Cul1 and Cul3 in Drosophila. Rencus-Lazar S, et al. PLoS One, 2008 May 21. PMID 18493598, Free PMC Article
    5. The TCT motif, a key component of an RNA polymerase II transcription system for the translational machinery. Parry TJ, et al. Genes Dev, 2010 Sep 15. PMID 20801935, Free PMC Article

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Depletion of Int6 results in short mitotic spindles and deformed centromeres and kinetochores. Int6-mediated ubiquitination is required to control the activity of Klp67A.
      Title: The Drosophila orthologue of the INT6 onco-protein regulates mitotic microtubule growth and kinetochore structure.
    2. Int6 and the COP9 signalosome play opposing roles in regulation of cullin neddylation
      Title: The proto-oncogene Int6 is essential for neddylation of Cul1 and Cul3 in Drosophila.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation initiation factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translational initiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic translation initiation factor 3 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of eukaryotic translation initiation factor 3 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic translation initiation factor 3 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 3 subunit e
    Names
    CG9677-PA
    Int6
    Int6 homologue
    eIF3e-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      16785242..16786941 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058037.5 → NP_477385.1  eukaryotic translation initiation factor 3 subunit e [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477385.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O77410, Q9VVA2
      UniProtKB/TrEMBL
      Q8MR88
      Related
      FBpp0075104
      Conserved Domains (1) summary
      cd21378
      Location:3 → 418
      eIF3E; eukaryotic translation initiation factor 3 subunit E
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O77410.1 O77410

    Gene LinkOut

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