U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Prp4k Pre-mRNA processing factor 4 kinase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38032, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Prp4kprovided by FlyBase
    Official Full Name
    Pre-mRNA processing factor 4 kinaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0027587
    Locus tag
    Dmel_CG7028
    See related
    AllianceGenome:FB:FBgn0027587
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GH04978; CG7028; Dmel\CG7028; prp4; PRP4; PRP4K
    Summary
    Enables protein serine/threonine kinase activity. Involved in positive regulation of hippo signaling. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in organism. Orthologous to human PRP4K (pre-mRNA processing factor kinase PRP4K). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Prp4k in Genome Data Viewer
    Location:
    61B2-61B2; 3-1 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (207184..211457, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (207184..211457, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene mrityu Neighboring gene Glycerol kinase 1 Neighboring gene Nitrilase and fragile histidine triad fusion protein Neighboring gene uncharacterized protein Neighboring gene thoc7 Neighboring gene Dis3 like 3'-5' exoribonuclease 2

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Spliceosome factors target timeless (tim) mRNA to control clock protein accumulation and circadian behavior in Drosophila. Shakhmantsir I, et al. Elife, 2018 Dec 5. PMID 30516472, Free PMC Article
    2. Regulation of Yki/Yap subcellular localization and Hpo signaling by a nuclear kinase PRP4K. Cho YS, et al. Nat Commun, 2018 Apr 25. PMID 29695716, Free PMC Article
    3. Hippo-Independent Regulation of Yki/Yap/Taz: A Non-canonical View. Cho YS, et al. Front Cell Dev Biol, 2021. PMID 33869224, Free PMC Article
    4. Cell cycle control of wnt receptor activation. Davidson G, et al. Dev Cell, 2009 Dec. PMID 20059949
    5. The computational analysis of scientific literature to define and recognize gene expression clusters. Raychaudhuri S, et al. Nucleic Acids Res, 2003 Aug 1. PMID 12888516, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA cis splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in positive regulation of hippo signaling IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome HDA PubMed 
    part_of precatalytic spliceosome HDA PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    Pre-mRNA processing factor 4 kinase
    Names
    CG7028-PA
    CG7028-PB
    CG7028-PC
    CG7028-PD
    CG7028-PE
    Prp4k-PA
    Prp4k-PB
    Prp4k-PC
    Prp4k-PD
    Prp4k-PE
    pre-mRNA processing 4
    NP_001261186.1
    NP_001286884.1
    NP_001286885.1
    NP_001286886.1
    NP_612010.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      207184..211457 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299957.1 → NP_001286886.1  Pre-mRNA processing factor 4 kinase, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286886.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9Y145
      Conserved Domains (2) summary
      smart00220
      Location:594 → 903
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14135
      Location:586 → 903
      STKc_PRP4; Catalytic domain of the Serine/Threonine Kinase, Pre-mRNA-Processing factor 4

    2. NM_001299956.1 → NP_001286885.1  Pre-mRNA processing factor 4 kinase, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286885.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JG22
      Conserved Domains (2) summary
      smart00220
      Location:593 → 902
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14135
      Location:585 → 902
      STKc_PRP4; Catalytic domain of the Serine/Threonine Kinase, Pre-mRNA-Processing factor 4

    3. NM_001274257.1 → NP_001261186.1  Pre-mRNA processing factor 4 kinase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261186.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PGI7
      Conserved Domains (2) summary
      smart00220
      Location:598 → 907
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14135
      Location:590 → 907
      STKc_PRP4; Catalytic domain of the Serine/Threonine Kinase, Pre-mRNA-Processing factor 4

    4. NM_138166.4 → NP_612010.1  Pre-mRNA processing factor 4 kinase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_612010.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9Y145
      Related
      FBpp0072427
      Conserved Domains (2) summary
      smart00220
      Location:594 → 903
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14135
      Location:586 → 903
      STKc_PRP4; Catalytic domain of the Serine/Threonine Kinase, Pre-mRNA-Processing factor 4

    5. NM_001299955.1 → NP_001286884.1  Pre-mRNA processing factor 4 kinase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286884.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JAG8
      Conserved Domains (2) summary
      smart00220
      Location:599 → 908
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14135
      Location:591 → 908
      STKc_PRP4; Catalytic domain of the Serine/Threonine Kinase, Pre-mRNA-Processing factor 4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PGI7 M9PGI7
    Q9Y145 Q9Y145
    X2JAG8 X2JAG8
    X2JG22 X2JG22

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools