Kank kank [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Kankprovided by FlyBase
Official Full Name: kankprovided by FlyBase
Primary source: FLYBASE:FBgn0027596
Locus tag: Dmel_CG10249
See related: AllianceGenome:FB:FBgn0027596
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA:GH03482; BEST:GH19041; CG10249; dKank; Dmel\CG10249; kank
Summary: Enables microtubule plus-end binding activity. Predicted to be involved in negative regulation of actin filament polymerization. Located in several cellular components, including microtubule plus-end; muscle tendon junction; and nucleus. Is expressed in several structures, including dorsal pharyngeal muscle cell; embryonic epipharynx; embryonic hypopharynx; gut section; and sensory nervous system primordium. Human ortholog(s) of this gene implicated in nephrotic syndrome type 16; palmoplantar keratoderma and woolly hair; and spastic quadriplegic cerebral palsy 2. Orthologous to several human genes including KANK1 (KN motif and ankyrin repeat domains 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 51D2-51D2; 2-73 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (14901475..14928425, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (10788980..10815930, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Kank as an EB1 interactor that predominantly localises to embryonic attachment sites between muscle and tendon cells
Title: Kank Is an EB1 interacting protein that localises to muscle-tendon attachment sites in Drosophila.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables microtubule plus-end binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of actin filament polymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of actin filament polymerization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule plus-end	IDA Inferred from Direct Assay more info	PubMed
located_in muscle tendon junction	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: kank

Names: CG10249-PA; CG10249-PB; CG10249-PC; CG10249-PD; CG10249-PE; CG10249-PF; CG10249-PG; CG10249-PI; CG10249-PJ; Kank-PA; Kank-PB; Kank-PC; Kank-PD; Kank-PE; Kank-PF; Kank-PG; Kank-PI; Kank-PJ

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

14901475..14928425 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001202004.2 → NP_001188933.1 kank, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001188933.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4JCT6, Q5BIA1

Conserved Domains (4) summary

cd00204
Location:1096 → 1227

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12075
Location:31 → 57

KN_motif; KN motif

pfam13637
Location:1176 → 1227

Ank_4; Ankyrin repeats (many copies)

sd00045
Location:1101 → 1170

ANK; ANK repeat [structural motif]
NM_001103848.2 → NP_001097318.1 kank, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001097318.1

Status: REVIEWED

UniProtKB/TrEMBL

A8DYE0, Q5BIA1

Conserved Domains (4) summary

cd00204
Location:1141 → 1272

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12075
Location:76 → 102

KN_motif; KN motif

pfam13637
Location:1221 → 1272

Ank_4; Ankyrin repeats (many copies)

sd00045
Location:1146 → 1215

ANK; ANK repeat [structural motif]
NM_166073.3 → NP_725426.1 kank, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_725426.1

Status: REVIEWED

UniProtKB/TrEMBL

A1Z9W5, Q5BIA1

Related

FBpp0086559

Conserved Domains (4) summary

cd00204
Location:1103 → 1234

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12075
Location:38 → 64

KN_motif; KN motif

pfam13637
Location:1183 → 1234

Ank_4; Ankyrin repeats (many copies)

sd00045
Location:1108 → 1177

ANK; ANK repeat [structural motif]
NM_137161.1 → NP_611005.1 kank, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_611005.1

Status: REVIEWED

UniProtKB/TrEMBL

Q5BIA1, Q7KMM8

Related

FBpp0086560, FBtr0087430

Conserved Domains (3) summary

cd00204
Location:1026 → 1157

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam13637
Location:1106 → 1157

Ank_4; Ankyrin repeats (many copies)

sd00045
Location:1031 → 1100

ANK; ANK repeat [structural motif]
NM_001274054.1 → NP_001260983.1 kank, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260983.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KF63, Q6NNY7

Conserved Domains (3) summary

cd00204
Location:841 → 972

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam13637
Location:921 → 972

Ank_4; Ankyrin repeats (many copies)

sd00045
Location:846 → 915

ANK; ANK repeat [structural motif]
NM_001202003.2 → NP_001188932.1 kank, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001188932.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4JD54, Q6NNY7

Conserved Domains (3) summary

cd00204
Location:865 → 996

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam13637
Location:945 → 996

Ank_4; Ankyrin repeats (many copies)

sd00045
Location:870 → 939

ANK; ANK repeat [structural motif]
NM_166074.2 → NP_725427.1 kank, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_725427.1

Status: REVIEWED

UniProtKB/TrEMBL

A1Z9W7, Q6NNY7

Related

FBpp0086561

Conserved Domains (3) summary

cd00204
Location:844 → 975

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam13637
Location:924 → 975

Ank_4; Ankyrin repeats (many copies)

sd00045
Location:849 → 918

ANK; ANK repeat [structural motif]
NM_001169684.3 → NP_001163155.1 kank, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163155.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JH70, Q6NNY7

Conserved Domains (3) summary

cd00204
Location:844 → 920

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam13857
Location:838 → 891

Ank_5; Ankyrin repeats (many copies)

sd00045
Location:849 → 881

ANK; ANK repeat [structural motif]
NM_001202005.2 → NP_001188934.1 kank, isoform J [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001188934.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4JD77, F2FBA1

Conserved Domains (3) summary

cd00204
Location:248 → 379

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam13637
Location:328 → 379

Ank_4; Ankyrin repeats (many copies)

sd00045
Location:253 → 322

ANK; ANK repeat [structural motif]

Nucleotide		Protein
Heading	Accession and Version	Protein

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
A0A0B4JCT6		A0A0B4JCT6
A0A0B4JD54		A0A0B4JD54
A0A0B4JD77		A0A0B4JD77
A0A0B4KF63		A0A0B4KF63
A1Z9W5		A1Z9W5
A1Z9W7		A1Z9W7
A8DYE0		A8DYE0
E1JH70		E1JH70
Q5BIA1		Q5BIA1
Q7KMM8		Q7KMM8