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    glo glorund [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41431, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gloprovided by FlyBase
    Official Full Name
    glorundprovided by FlyBase
    Primary source
    FLYBASE:FBgn0259139
    Locus tag
    Dmel_CG6946
    See related
    AllianceGenome:FB:FBgn0259139
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    110/46; anon-WO0118547.328; cg6946; CG6946; Dmel\CG6946; Glo; l(3)S011046; l(3)S11046; p67; p67-K
    Summary
    Predicted to enable mRNA binding activity. Involved in chromosome organization; oocyte axis specification; and regulation of translation. Part of protein-containing complex. Is expressed in adult head; embryonic brain; embryonic/larval midgut; larval ventral nerve cord; and organism. Human ortholog(s) of this gene implicated in Sjogren's syndrome and syndromic X-linked intellectual developmental disorder bain type. Orthologous to several human genes including HNRNPF (heterogeneous nuclear ribonucleoprotein F) and HNRNPH2 (heterogeneous nuclear ribonucleoprotein H2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See glo in Genome Data Viewer
    Location:
    86F8-86F9; 3-51 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (11815206..11819420, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7640928..7645061, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Histamine-gated chloride channel subunit 1 Neighboring gene SET domain binding factor Neighboring gene Chloride channel-a Neighboring gene Cytochrome c oxidase subunit 5A Neighboring gene Kynurenine aminotransferase Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sense and antisense RNA are not toxic in Drosophila models of C9orf72-associated ALS/FTD. Moens TG, et al. Acta Neuropathol, 2018 Mar. PMID 29380049, Free PMC Article
    2. The translational repressor Glorund uses interchangeable RNA recognition domains to recognize Drosophila nanos. Warden MS, et al. Nucleic Acids Res, 2023 Sep 8. PMID 37427795, Free PMC Article
    3. The role of HnrnpF/H as a driver of oligoteratozoospermia. Netherton JK, et al. iScience, 2024 Jul 19. PMID 39092172, Free PMC Article
    4. Multiple mechanisms collaborate to repress nanos translation in the Drosophila ovary and embryo. Andrews S, et al. RNA, 2011 May. PMID 21460235, Free PMC Article
    5. Spatial regulation of nanos is required for its function in dendrite morphogenesis. Brechbiel JL, et al. Curr Biol, 2008 May 20. PMID 18472422, Free PMC Article

    See all (78) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The translational repressor Glorund uses interchangeable RNA recognition domains to recognize Drosophila nanos.
      Title: The translational repressor Glorund uses interchangeable RNA recognition domains to recognize Drosophila nanos.
    2. The Drosophila hnRNP F/H homolog Glorund recruits dFMRP to inhibit nanos translation elongation.
      Title: The Drosophila hnRNP F/H homolog Glorund recruits dFMRP to inhibit nanos translation elongation.
    3. these findings suggest a molecular mechanism for the evolution of dual RNA motif recognition in Glo that may be applied to understanding the functional diversity of other RNA-binding proteins.
      Title: The Drosophila hnRNP F/H Homolog Glorund Uses Two Distinct RNA-Binding Modes to Diversify Target Recognition.
    4. Glorund is a component of multiple protein complexes and functions both as a translational repressor and splicing regulator for anterior-posterior and dorsal-ventral patterning.
      Title: Glorund interactions in the regulation of gurken and oskar mRNAs.
    5. These data, together with the analysis of a glorund null mutant, reveal a specific role for an hnRNP in repression of nanos translation during oogenesis.
      Title: Glorund, a Drosophila hnRNP F/H homolog, is an ovarian repressor of nanos translation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromosome organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular mRNA localization involved in pattern specification process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in maternal specification of dorsal/ventral axis, oocyte, germ-line encoded IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pole plasm oskar mRNA localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of RNA splicing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in wound healing HMP PubMed 
    Component Evidence Code Pubs
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein-containing complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    glorund
    Names
    CG6946-PA
    CG6946-PB
    CG6946-PC
    CG6946-PD
    glo-PA
    glo-PB
    glo-PC
    glo-PD
    p67-K

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      11815206..11819420 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169435.3 → NP_731640.1  glorund, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731640.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8INJ6
      Related
      FBpp0088857
      Conserved Domains (2) summary
      COG0724
      Location:20 → 179
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cl17169
      Location:51 → 125
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. NM_169434.3 → NP_731639.1  glorund, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731639.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VGH5
      Related
      FBpp0088856
      Conserved Domains (3) summary
      cd12504
      Location:146 → 224
      RRM2_hnRNPH_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein (hnRNP) H protein family
      cd12506
      Location:481 → 555
      RRM3_hnRNPH_CRSF1_like; RNA recognition motif 3 in heterogeneous nuclear ribonucleoprotein hnRNP H protein family, G-rich sequence factor 1 (GRSF-1) and similar proteins
      cl17169
      Location:51 → 125
      RRM_SF; RNA recognition motif (RRM) superfamily

    3. NM_001414143.1 → NP_001401043.1  glorund, isoform D [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VGH5

    4. NM_141863.3 → NP_650120.1  glorund, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650120.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VGH5
      Related
      FBpp0088858
      Conserved Domains (3) summary
      cd12504
      Location:146 → 224
      RRM2_hnRNPH_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein (hnRNP) H protein family
      cd12506
      Location:481 → 555
      RRM3_hnRNPH_CRSF1_like; RNA recognition motif 3 in heterogeneous nuclear ribonucleoprotein hnRNP H protein family, G-rich sequence factor 1 (GRSF-1) and similar proteins
      cl17169
      Location:51 → 125
      RRM_SF; RNA recognition motif (RRM) superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IG99 Q8IG99
    Q8INJ6 Q8INJ6
    Q9VGH5 Q9VGH5

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