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    jim jim [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43924, updated on 17-Dec-2024

    Summary

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    Official Symbol
    jimprovided by FlyBase
    Official Full Name
    jimprovided by FlyBase
    Primary source
    FLYBASE:FBgn0027339
    Locus tag
    Dmel_CG11352
    See related
    AllianceGenome:FB:FBgn0027339
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:SD14927; CG11352; Dmel\CG11352; Jim; ovfc.K; ovk; OVK
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in dendrite morphogenesis. Is expressed in several structures, including follicle cell; ganglia; gut section; and pharyngeal muscle cell. Orthologous to several human genes including ZNF502 (zinc finger protein 502); ZNF678 (zinc finger protein 678); and ZNF679 (zinc finger protein 679). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See jim in Genome Data Viewer
    Location:
    80A2-80A4; 3-47 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (22789233..22835194, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (22782333..22828294, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45961 Neighboring gene Secretory Pathway Calcium atpase Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45659 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Differential expression of the Drosophila zinc finger gene jim in the follicular epithelium. Doerflinger H, et al. Mech Dev, 1999 Aug. PMID 10446279
    2. The Kinase Activity of Drosophila BubR1 Is Required for Insulin Signaling-Dependent Stem Cell Maintenance. Tang R, et al. Cell Rep, 2020 Jun 23. PMID 32579921
    3. Novel subcellular locations and functions for secretory pathway Ca2+/Mn2+-ATPases. Southall TD, et al. Physiol Genomics, 2006 Jun 16. PMID 16609144
    4. Age-Dependent Changes in Transcription Factor FOXO Targeting in Female Drosophila. Birnbaum A, et al. Front Genet, 2019. PMID 31134124, Free PMC Article
    5. Post-transcriptional regulation of transcription factor codes in immature neurons drives neuronal diversity. Guan W, et al. Cell Rep, 2022 Jun 28. PMID 35767953, Free PMC Article

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    jim
    Names
    CG11352-PC
    CG11352-PD
    CG11352-PE
    CG11352-PF
    CG11352-PG
    CG11352-PH
    CG11352-PI
    jim-PC
    jim-PD
    jim-PE
    jim-PF
    jim-PG
    jim-PH
    jim-PI

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      22789233..22835194 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143699.4 → NP_651956.1  jim, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651956.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NN10, Q7KAH0
      Related
      FBpp0078231
      Conserved Domains (5) summary
      COG5048
      Location:355 → 666
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:359 → 379
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:553 → 575
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:596 → 620
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:327 → 382
      zf-C2H2_8; C2H2-type zinc ribbon

    2. NM_001259959.2 → NP_001246888.1  jim, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246888.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NFP1, Q6NN10
      Conserved Domains (5) summary
      COG5048
      Location:355 → 671
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:359 → 379
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:557 → 579
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:600 → 624
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:327 → 382
      zf-C2H2_8; C2H2-type zinc ribbon

    3. NM_001275292.1 → NP_001262221.1  jim, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262221.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PGG2, Q6NN10
      Conserved Domains (4) summary
      COG5048
      Location:355 → 666
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:359 → 379
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:553 → 575
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:596 → 620
      zf-H2C2_2; Zinc-finger double domain

    4. NM_001275294.1 → NP_001262223.1  jim, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262223.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PIL6, Q6NN10
      Conserved Domains (4) summary
      COG5048
      Location:355 → 638
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:527 → 547
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:525 → 547
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:568 → 592
      zf-H2C2_2; Zinc-finger double domain

    5. NM_001275293.1 → NP_001262222.1  jim, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262222.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PG92, Q6NN10
      Conserved Domains (4) summary
      COG5048
      Location:355 → 640
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:527 → 547
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:525 → 547
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:568 → 592
      zf-H2C2_2; Zinc-finger double domain

    6. NM_168964.5 → NP_730746.1  jim, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730746.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NN10, Q7KAH0
      Related
      FBpp0305414
      Conserved Domains (5) summary
      COG5048
      Location:355 → 666
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:359 → 379
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:553 → 575
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:596 → 620
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:327 → 382
      zf-C2H2_8; C2H2-type zinc ribbon

    7. NM_001014601.1 → NP_001014601.1  jim, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014601.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NN10, Q7KAH0
      Conserved Domains (5) summary
      COG5048
      Location:355 → 666
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:359 → 379
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:553 → 575
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:596 → 620
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:327 → 382
      zf-C2H2_8; C2H2-type zinc ribbon
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9NFP1 M9NFP1
    M9PG92 M9PG92
    M9PGG2 M9PGG2
    M9PIL6 M9PIL6
    Q7KAH0 Q7KAH0
    Q8IG96 Q8IG96

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