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    CG9391 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40346, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG9391provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037063
    Locus tag
    Dmel_CG9391
    See related
    AllianceGenome:FB:FBgn0037063
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    142335_at; Dmel\CG9391; IMP
    Summary
    Predicted to enable inositol monophosphate 1-phosphatase activity. Predicted to be involved in inositol metabolic process and signal transduction. Predicted to be located in cytoplasm. Is expressed in Bolwig organ; adult head; adult heart; organism; and spermatozoon. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 59; bipolar disorder; intellectual disability; and schizophrenia. Orthologous to several human genes including IMPA2 (inositol monophosphatase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG9391 in Genome Data Viewer
    Location:
    78C3-78C3; 3-47 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21266680..21268335, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21259780..21261435, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Ecdysone-induced protein 78C Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45162 Neighboring gene uncharacterized protein Neighboring gene Acetyl Coenzyme A synthase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. E2 ligase dRad6 regulates DMP53 turnover in Drosophila. Chen S, et al. J Biol Chem, 2011 Mar 18. PMID 21205821, Free PMC Article
    2. A conserved myotubularin-related phosphatase regulates autophagy by maintaining autophagic flux. Allen EA, et al. J Cell Biol, 2020 Nov 2. PMID 32915229, Free PMC Article
    3. Transcription profiling in Drosophila eyes that overexpress the human glaucoma-associated trabecular meshwork-inducible glucocorticoid response protein/myocilin (TIGR/MYOC). Borrás T, et al. Genetics, 2003 Feb. PMID 12618402, Free PMC Article
    4. Inferring gene function and network organization in Drosophila signaling by combined analysis of pleiotropy and epistasis. Carter GW. G3 (Bethesda), 2013 May 20. PMID 23550134, Free PMC Article
    5. Mating-responsive genes in reproductive tissues of female Drosophila melanogaster. Mack PD, et al. Proc Natl Acad Sci U S A, 2006 Jul 5. PMID 16798875, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables inositol monophosphate 1-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables inositol monophosphate 1-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inositol monophosphate 1-phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in inositol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylinositol phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG9391-PA
    CG9391-PC
    NP_649294.1
    NP_730610.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      21266680..21268335 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168893.3 → NP_730610.3  uncharacterized protein Dmel_CG9391, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730610.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KTW5
      Conserved Domains (1) summary
      cd01639
      Location:10 → 255
      IMPase; IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be ...

    2. NM_141037.5 → NP_649294.1  uncharacterized protein Dmel_CG9391, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649294.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KTW5
      Related
      FBpp0078071
      Conserved Domains (1) summary
      cd01639
      Location:10 → 255
      IMPase; IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KTW5 Q7KTW5

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