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    fmt fiery mountain [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38714, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fmtprovided by FlyBase
    Official Full Name
    fiery mountainprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035688
    Locus tag
    Dmel_CG10289
    See related
    AllianceGenome:FB:FBgn0035688
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10289; Dmel\CG10289; PpV[[R]]
    Summary
    Predicted to enable protein phosphatase regulator activity. Involved in negative regulation of JNK cascade. Predicted to be active in cytosol and nucleus. Is expressed in adult head. Orthologous to human PPP6R1 (protein phosphatase 6 regulatory subunit 1); PPP6R2 (protein phosphatase 6 regulatory subunit 2); and PPP6R3 (protein phosphatase 6 regulatory subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See fmt in Genome Data Viewer
    Location:
    65A7-65A7; 3-16 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (6164916..6173880, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (6158016..6166980, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45744 Neighboring gene PR/SET domain 13 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene D19B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila protein phosphatase V regulates lipid homeostasis via the AMPK pathway. Yin D, et al. J Mol Cell Biol, 2014 Feb. PMID 24334257
    2. Global analysis of short RNAs reveals widespread promoter-proximal stalling and arrest of Pol II in Drosophila. Nechaev S, et al. Science, 2010 Jan 15. PMID 20007866, Free PMC Article
    3. Competition between two phosphatases fine-tunes Hedgehog signaling. Liu M, et al. J Cell Biol, 2021 Feb 1. PMID 33373452, Free PMC Article
    4. PP6 Disruption Synergizes with Oncogenic Ras to Promote JNK-Dependent Tumor Growth and Invasion. Ma X, et al. Cell Rep, 2017 Jun 27. PMID 28658615, Free PMC Article
    5. Bip-Yorkie interaction determines oncogenic and tumor-suppressive roles of Ire1/Xbp1s activation. Yang S, et al. Proc Natl Acad Sci U S A, 2022 Oct 18. PMID 36215479, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein phosphatase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein phosphatase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of JNK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    fiery mountain
    Names
    CG10289-PA
    CG10289-PB
    CG10289-PC
    CG10289-PD
    fmt-PA
    fmt-PB
    fmt-PC
    fmt-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      6164916..6173880 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274540.1 → NP_001261469.1  fiery mountain, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261469.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95R81, Q9VRV1
      Conserved Domains (1) summary
      pfam04499
      Location:129 → 465
      SAPS; SIT4 phosphatase-associated protein

    2. NM_139776.3 → NP_648033.2  fiery mountain, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648033.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95R81, Q9VRV1
      Related
      FBpp0076727
      Conserved Domains (1) summary
      pfam04499
      Location:129 → 465
      SAPS; SIT4 phosphatase-associated protein

    3. NM_001274539.1 → NP_001261468.1  fiery mountain, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261468.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PEB1, Q95R81
      Conserved Domains (1) summary
      pfam04499
      Location:129 → 465
      SAPS; SIT4 phosphatase-associated protein

    4. NM_001274541.1 → NP_001261470.1  fiery mountain, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261470.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PEH8, Q95R81
      Conserved Domains (1) summary
      pfam04499
      Location:129 → 465
      SAPS; SIT4 phosphatase-associated protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PEB1 M9PEB1
    M9PEH8 M9PEH8
    Q95R81 Q95R81
    Q9VRV1 Q9VRV1

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