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    ZNF765 zinc finger protein 765 [ Homo sapiens (human) ]

    Gene ID: 91661, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ZNF765provided by HGNC
    Official Full Name
    zinc finger protein 765provided by HGNC
    Primary source
    HGNC:HGNC:25092
    See related
    Ensembl:ENSG00000196417 AllianceGenome:HGNC:25092
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in ovary (RPKM 4.5), testis (RPKM 2.5) and 25 other tissues See more
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    Genomic context

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    See ZNF765 in Genome Data Viewer
    Location:
    19q13.42
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (53395149..53427321)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (56474647..56506876)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (53898402..53930574)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 845 Neighboring gene putative zinc finger protein 137 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11007 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15066 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11008 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:53872557-53873058 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:53873059-53873558 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr19:53877455-53878025 Neighboring gene zinc finger protein 525 Neighboring gene ribosomal protein L39 pseudogene 35 Neighboring gene ZNF765-ZNF761 readthrough Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11009 Neighboring gene putative zinc finger protein 137 Neighboring gene ribosomal protein L39 pseudogene 36 Neighboring gene vomeronasal 1 receptor 101 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11010 Neighboring gene tropomyosin 3 pseudogene 9 Neighboring gene zinc finger protein 761 Neighboring gene Sharpr-MPRA regulatory region 10215 Neighboring gene vomeronasal 1 receptor 102 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. IGF2BP2 stabilized FBXL19-AS1 regulates the blood-tumour barrier permeability by negatively regulating ZNF765 by STAU1-mediated mRNA decay. Liu X, et al. RNA Biol, 2020 Dec. PMID 32713259, Free PMC Article
    2. The interactome of KRAB zinc finger proteins reveals the evolutionary history of their functional diversification. Helleboid PY, et al. EMBO J, 2019 Sep 16. PMID 31403225, Free PMC Article
    3. The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery. Kumar R, et al. Nat Commun, 2017 Nov 27. PMID 29180619, Free PMC Article
    4. VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Yue Y, et al. Cell Discov, 2018. PMID 29507755, Free PMC Article
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. IGF2BP2 stabilized FBXL19-AS1 regulates the blood-tumour barrier permeability by negatively regulating ZNF765 by STAU1-mediated mRNA decay.
      Title: IGF2BP2 stabilized FBXL19-AS1 regulates the blood-tumour barrier permeability by negatively regulating ZNF765 by STAU1-mediated mRNA decay.
    2. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Readthrough ZNF765-ZNF761

    Readthrough gene: ZNF765-ZNF761, Included gene: ZNF525, Included gene: ZNF761

    Homology

    Clone Names

    • FLJ30902, DKFZp686J2252

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 765

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040185.3 → NP_001035275.1  zinc finger protein 765 isoform 1

      See identical proteins and their annotated locations for NP_001035275.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC022137, CD656338
      Consensus CDS
      CCDS46171.1
      UniProtKB/Swiss-Prot
      A8MYG0, B4DF18, B7ZAI5, B9EIL1, Q7L2R6, Q9BV49
      Related
      ENSP00000379689.3, ENST00000396408.8
      Conserved Domains (5) summary
      smart00349
      Location:8 → 48
      KRAB; krueppel associated box
      COG5048
      Location:325 → 477
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:329 → 349
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:8 → 47
      KRAB; KRAB box
      pfam13465
      Location:314 → 338
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001350495.2 → NP_001337424.1  zinc finger protein 765 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC022137
      Conserved Domains (3) summary
      COG5048
      Location:272 → 424
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:276 → 296
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:204 → 229
      zf-H2C2_2; Zinc-finger double domain

    RNA

    1. NR_146721.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC022137, BC017357
      Related
      ENST00000504235.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      53395149..53427321
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      56474647..56506876
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7L2R6.2 GenPept UniProtKB/Swiss-Prot:Q7L2R6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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