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    ANXA10 annexin A10 [ Homo sapiens (human) ]

    Gene ID: 11199, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ANXA10provided by HGNC
    Official Full Name
    annexin A10provided by HGNC
    Primary source
    HGNC:HGNC:534
    See related
    Ensembl:ENSG00000109511 MIM:608008; AllianceGenome:HGNC:534
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ANX14
    Summary
    This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. The function of this gene has not yet been determined. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in stomach (RPKM 190.8), urinary bladder (RPKM 26.5) and 1 other tissue See more
    Orthologs
    mouse all
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    Genomic context

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    See ANXA10 in Genome Data Viewer
    Location:
    4q32.3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (168092537..168187736)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (171451471..171546783)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (169013688..169108887)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene RN7SK pseudogene 188 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:168778932-168779432 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:168797178-168797908 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr4:168817975-168819174 Neighboring gene uncharacterized LOC105377523 Neighboring gene uncharacterized LOC124900170 Neighboring gene uncharacterized LOC105377524 Neighboring gene DExD/H-box helicase 60 Neighboring gene small nucleolar RNA U13 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22124 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_76106 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_76110 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_76113 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_76114 Neighboring gene DExD/H-box 60 like Neighboring gene small nucleolar RNA SNORA51

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Effects of over-expression of ANXA10 gene on proliferation and apoptosis of hepatocellular carcinoma cell line HepG2. Liu X, et al. J Huazhong Univ Sci Technolog Med Sci, 2012 Oct. PMID 23073794
    2. Annexin A10 is a candidate marker associated with the progression of pancreatic precursor lesions to adenocarcinoma. Zhu J, et al. PLoS One, 2017. PMID 28369074, Free PMC Article
    3. Annexin A10 expression in colorectal cancers with emphasis on the serrated neoplasia pathway. Bae JM, et al. World J Gastroenterol, 2015 Sep 7. PMID 26361422, Free PMC Article
    4. ANXA10 induction by interaction with tumor-associated macrophages promotes the growth of esophageal squamous cell carcinoma. Kodaira H, et al. Pathol Int, 2019 Mar. PMID 30758105, Free PMC Article
    5. Annexin A10 is a marker for the serrated pathway of colorectal carcinoma. Sajanti SA, et al. Virchows Arch, 2015 Jan. PMID 25395067

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SOX2-Induced Linc-ROR Upregulation Inhibits Gastric Carcinoma Cell Proliferation and Metastasis Via the miR-580-3p/ANXA10 Pathway.
      Title: SOX2-Induced Linc-ROR Upregulation Inhibits Gastric Carcinoma Cell Proliferation and Metastasis Via the miR-580-3p/ANXA10 Pathway.
    2. ANXA10 Expression Is Inversely Associated with Tumor Stage, Grade, and TP53 Expression in Upper and Lower Urothelial Carcinoma.
      Title: ANXA10 Expression Is Inversely Associated with Tumor Stage, Grade, and TP53 Expression in Upper and Lower Urothelial Carcinoma.
    3. Strong Annexin A10 Expression Supports a Pancreatic Primary and Combined Annexin A10, Claudin 18, and SOX2 Expression Supports an Esophagogastric Origin in Carcinomas of Unknown Primary.
      Title: Strong Annexin A10 Expression Supports a Pancreatic Primary and Combined Annexin A10, Claudin 18, and SOX2 Expression Supports an Esophagogastric Origin in Carcinomas of Unknown Primary.
    4. ANXA10 is a prognostic biomarker and suppressor of hepatocellular carcinoma: a bioinformatics analysis and experimental validation.
      Title: ANXA10 is a prognostic biomarker and suppressor of hepatocellular carcinoma: a bioinformatics analysis and experimental validation.
    5. GATA6 regulates expression of annexin A10 (ANXA10) associated with epithelial-mesenchymal transition of oral squamous cell carcinoma.
      Title: GATA6 regulates expression of annexin A10 (ANXA10) associated with epithelial-mesenchymal transition of oral squamous cell carcinoma.
    6. The prognostic significance of annexin A family in glioblastoma.
      Title: The prognostic significance of annexin A family in glioblastoma.
    7. High Annexin A10 expression is correlated with poor prognosis in pancreatic ductal adenocarcinoma.
      Title: High Annexin A10 expression is correlated with poor prognosis in pancreatic ductal adenocarcinoma.
    8. Association of annexin A10 expression with poor prognosis of intrahepatic cholangiocarcinoma.
      Title: Association of annexin A10 expression with poor prognosis of intrahepatic cholangiocarcinoma.
    9. Transcriptomic Analysis of Annexin A10 and Chemosensitivity in Gastric Adenocarcinoma Cells.
      Title: Transcriptomic Analysis of Annexin A10 and Chemosensitivity in Gastric Adenocarcinoma Cells.
    10. Annexin A10 Expression as a Novel Prognostic Marker in Lung Adenocarcinoma.
      Title: Annexin A10 Expression as a Novel Prognostic Marker in Lung Adenocarcinoma.
    Submit: New GeneRIF Correction See all GeneRIFs (33)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium-dependent phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylserine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    annexin A10
    Names
    annexin 14
    annexin-10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007193.5 → NP_009124.2  annexin A10

      See identical proteins and their annotated locations for NP_009124.2

      Status: REVIEWED

      Source sequence(s)
      AC068989, BC007320, BM768053
      Consensus CDS
      CCDS34096.1
      UniProtKB/Swiss-Prot
      Q96IQ5, Q9UJ72, Q9UJV4
      Related
      ENSP00000352248.3, ENST00000359299.8
      Conserved Domains (1) summary
      pfam00191
      Location:93 → 158
      Annexin; Annexin

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      168092537..168187736
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011531571.3 → XP_011529873.1  annexin A10 isoform X1

      Conserved Domains (1) summary
      pfam00191
      Location:113 → 178
      Annexin; Annexin

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      171451471..171546783
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054348837.1 → XP_054204812.1  annexin A10 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UJ72.3 GenPept UniProtKB/Swiss-Prot:Q9UJ72

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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