NKIRAS2 NFKB inhibitor interacting Ras like 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: NKIRAS2provided by HGNC
Official Full Name: NFKB inhibitor interacting Ras like 2provided by HGNC
Primary source: HGNC:HGNC:17898
See related: Ensembl:ENSG00000168256 MIM:604497; AllianceGenome:HGNC:17898
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: KBRAS2; kappaB-Ras2
Summary: Predicted to enable GTPase activating protein binding activity. Predicted to be involved in Ral protein signal transduction. Predicted to act upstream of or within several processes, including lung alveolus development; regulation of signal transduction; and surfactant homeostasis. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in placenta (RPKM 30.4), esophagus (RPKM 22.7) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 17q21.2

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (42017576..42025641)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (42874107..42882171)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (40169594..40177659)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

K15 promoter-driven enforced expression of NKIRAS exhibits tumor suppressive activity against the development of DMBA/TPA-induced skin tumors.
Title: K15 promoter-driven enforced expression of NKIRAS exhibits tumor suppressive activity against the development of DMBA/TPA-induced skin tumors.
GBM cells overexpressing TNFAIP3 and NKIRAS2 were refractory to miR-125b-induced apoptosis resistance as well as TMZ resistance, indicating that both genes are relevant targets of miR-125b.
Title: miR-125b controls apoptosis and temozolomide resistance by targeting TNFAIP3 and NKIRAS2 in glioblastomas.
KappaB-Ras2 is a nuclear-cytoplasmic small GTPase that inhibits NF-kappaB activation through the suppression of transcriptional activation of p65/RelA.
Title: KappaB-Ras is a nuclear-cytoplasmic small GTPase that inhibits NF-kappaB activation through the suppression of transcriptional activation of p65/RelA.
Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variation in the nuclear factor kappaB pathway in relation to susceptibility to rheumatoid arthritis.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

GDB:434012 (e-PCR)
- UniSTS:157204

WI-12446 (e-PCR)
- UniSTS:78126

D8S2279 (e-PCR)
- UniSTS:473907

D6S1611 (e-PCR)
- UniSTS:464200

A001U04 (e-PCR)
- UniSTS:34892

D15S1477 (e-PCR)
- UniSTS:474482

WI-21902 (e-PCR)
- UniSTS:74924

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activating protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in Ral protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in lung alveolus development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of canonical NF-kappaB signal transduction	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of tumor necrosis factor-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in surfactant homeostasis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: NF-kappa-B inhibitor-interacting Ras-like protein 2

Names: I-kappa-B-interacting Ras-like protein 2; NFKB inhibitor interacting Ras-like protein 2; kappa B-Ras protein 2

NP_001001349.1

EC 3.6.5.1

EC 3.6.5.2

EC 3.6.5.3

EC 3.6.5.4

NP_001138399.1

EC 3.6.5.1

EC 3.6.5.2

EC 3.6.5.3

EC 3.6.5.4

NP_001138400.1

EC 3.6.5.1

EC 3.6.5.2

EC 3.6.5.3

EC 3.6.5.4

NP_001138401.1

EC 3.6.5.1

EC 3.6.5.2

EC 3.6.5.3

EC 3.6.5.4

NP_060065.2

EC 3.6.5.1

EC 3.6.5.2

EC 3.6.5.3

EC 3.6.5.4

XP_047291778.1

EC 3.6.5.1

EC 3.6.5.2

EC 3.6.5.3

EC 3.6.5.4

XP_047291779.1

EC 3.6.5.1

EC 3.6.5.2

EC 3.6.5.3

EC 3.6.5.4

XP_047291781.1

EC 3.6.5.1

EC 3.6.5.2

EC 3.6.5.3

EC 3.6.5.4

XP_047291782.1

EC 3.6.5.1

EC 3.6.5.2

EC 3.6.5.3

EC 3.6.5.4

XP_054171807.1

EC 3.6.5.1

EC 3.6.5.2

EC 3.6.5.3

EC 3.6.5.4

XP_054171808.1

EC 3.6.5.1

EC 3.6.5.2

EC 3.6.5.3

EC 3.6.5.4

XP_054171809.1

EC 3.6.5.1

EC 3.6.5.2

EC 3.6.5.3

EC 3.6.5.4

XP_054171810.1

EC 3.6.5.1

EC 3.6.5.2

EC 3.6.5.3

EC 3.6.5.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001001349.2 → NP_001001349.1 NF-kappa-B inhibitor-interacting Ras-like protein 2 isoform a

See identical proteins and their annotated locations for NP_001001349.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes isoform a. Variants 1-3 encode the same protein (isoform a).

Source sequence(s)

AC105024, BC063498

Consensus CDS

CCDS11415.1

UniProtKB/Swiss-Prot

A6NCZ5, B3KNN0, B4DNM3, Q6PK52, Q96KC7, Q9NSX1, Q9NYR9

UniProtKB/TrEMBL

H7BXP1

Related

ENSP00000303580.5, ENST00000307641.9

Conserved Domains (1) summary

cl38936
Location:6 → 168

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_001144927.2 → NP_001138399.1 NF-kappa-B inhibitor-interacting Ras-like protein 2 isoform a

See identical proteins and their annotated locations for NP_001138399.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1, and encodes isoform a. Variants 1-3 encode the same protein (isoform a).

Source sequence(s)

AC105024, BC063498, DA607452

Consensus CDS

CCDS11415.1

UniProtKB/Swiss-Prot

A6NCZ5, B3KNN0, B4DNM3, Q6PK52, Q96KC7, Q9NSX1, Q9NYR9

UniProtKB/TrEMBL

H7BXP1

Related

ENSP00000377459.3, ENST00000393881.7

Conserved Domains (1) summary

cl38936
Location:6 → 168

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_001144928.2 → NP_001138400.1 NF-kappa-B inhibitor-interacting Ras-like protein 2 isoform b

See identical proteins and their annotated locations for NP_001138400.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and lacks an in-frame segment of the coding region, compared to variant 1. These differences result in a shorter protein (isoform b), compared to isoform a.

Source sequence(s)

AC105024, AK297975, BC063498, BG717103

Consensus CDS

CCDS45679.1

UniProtKB/Swiss-Prot

Q9NYR9

Related

ENSP00000401976.4, ENST00000449471.8

Conserved Domains (1) summary

cl38936
Location:6 → 112

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_001144929.2 → NP_001138401.1 NF-kappa-B inhibitor-interacting Ras-like protein 2 isoform c

See identical proteins and their annotated locations for NP_001138401.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR and lacks a segment of the coding region, compared to variant 1. These differences result in a shorter protein (isoform c) with a novel C-terminus, compared to isoform a.

Source sequence(s)

AC105024, BC063498, BG717103, DA509824

Consensus CDS

CCDS45680.1

UniProtKB/Swiss-Prot

Q9NYR9

Related

ENSP00000465633.1, ENST00000479407.5

Conserved Domains (1) summary

cd00882
Location:8 → 52

Ras_like_GTPase; Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases)
NM_017595.6 → NP_060065.2 NF-kappa-B inhibitor-interacting Ras-like protein 2 isoform a

See identical proteins and their annotated locations for NP_060065.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1, and encodes isoform a. Variants 1-3 encode the same protein (isoform a).

Source sequence(s)

AC105024, BC007316, BC063498, BG717103

Consensus CDS

CCDS11415.1

UniProtKB/Swiss-Prot

A6NCZ5, B3KNN0, B4DNM3, Q6PK52, Q96KC7, Q9NSX1, Q9NYR9

UniProtKB/TrEMBL

H7BXP1

Related

ENSP00000377463.3, ENST00000393885.9

Conserved Domains (1) summary

cl38936
Location:6 → 168

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000017.11 Reference GRCh38.p14 Primary Assembly

Range

42017576..42025641

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047435823.1 → XP_047291779.1 NF-kappa-B inhibitor-interacting Ras-like protein 2 isoform X1

UniProtKB/Swiss-Prot

A6NCZ5, B3KNN0, B4DNM3, Q6PK52, Q96KC7, Q9NSX1, Q9NYR9

UniProtKB/TrEMBL

H7BXP1
XM_047435822.1 → XP_047291778.1 NF-kappa-B inhibitor-interacting Ras-like protein 2 isoform X1

UniProtKB/Swiss-Prot

A6NCZ5, B3KNN0, B4DNM3, Q6PK52, Q96KC7, Q9NSX1, Q9NYR9

UniProtKB/TrEMBL

H7BXP1
XM_047435825.1 → XP_047291781.1 NF-kappa-B inhibitor-interacting Ras-like protein 2 isoform X2
XM_047435826.1 → XP_047291782.1 NF-kappa-B inhibitor-interacting Ras-like protein 2 isoform X2

Alternate T2T-CHM13v2.0

Genomic

NC_060941.1 Alternate T2T-CHM13v2.0

Range

42874107..42882171

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054315833.1 → XP_054171808.1 NF-kappa-B inhibitor-interacting Ras-like protein 2 isoform X1

UniProtKB/Swiss-Prot

A6NCZ5, B3KNN0, B4DNM3, Q6PK52, Q96KC7, Q9NSX1, Q9NYR9

UniProtKB/TrEMBL

H7BXP1
XM_054315832.1 → XP_054171807.1 NF-kappa-B inhibitor-interacting Ras-like protein 2 isoform X1

UniProtKB/Swiss-Prot

A6NCZ5, B3KNN0, B4DNM3, Q6PK52, Q96KC7, Q9NSX1, Q9NYR9

UniProtKB/TrEMBL

H7BXP1
XM_054315834.1 → XP_054171809.1 NF-kappa-B inhibitor-interacting Ras-like protein 2 isoform X2
XM_054315835.1 → XP_054171810.1 NF-kappa-B inhibitor-interacting Ras-like protein 2 isoform X2