dnai2a dynein, axonemal, intermediate chain 2a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: dnai2aprovided by ZNC
Official Full Name: dynein, axonemal, intermediate chain 2aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-070410-46
See related: Ensembl:ENSDARG00000100285 AllianceGenome:ZFIN:ZDB-GENE-070410-46
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:162235
Summary: Predicted to enable dynein heavy chain binding activity and dynein light chain binding activity. Predicted to be involved in cilium movement and outer dynein arm assembly. Predicted to be located in cell projection; cytoplasm; and microtubule. Predicted to be part of outer dynein arm. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 9. Orthologous to human DNAI2 (dynein axonemal intermediate chain 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 12

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (35937098..35944547, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (36242530..36250292, complement)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables dynein heavy chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables dynein light chain binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cilium movement	IBA Inferred from Biological aspect of Ancestor more info
involved_in outer dynein arm assembly	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
part_of dynein complex	IEA Inferred from Electronic Annotation more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
part_of outer dynein arm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: dynein, axonemal, intermediate chain 2a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001110465.1 → NP_001103935.1 dynein, axonemal, intermediate chain 2a

See identical proteins and their annotated locations for NP_001103935.1

Status: PROVISIONAL

Source sequence(s)

BC152581

UniProtKB/TrEMBL

A0A0R4IUW7, A0A8M6Z1Y7, A7YYA2

Related

ENSDARP00000133476.1, ENSDART00000164199.2

Conserved Domains (3) summary

COG2319
Location:160 → 489

WD40; WD40 repeat [General function prediction only]

sd00039
Location:160 → 208

7WD40; WD40 repeat [structural motif]

cl02567
Location:189 → 469

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...