ttc21b tetratricopeptide repeat domain 21B [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ttc21bprovided by ZNC
Official Full Name: tetratricopeptide repeat domain 21Bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-031010-34
See related: Ensembl:ENSDARG00000012368 AllianceGenome:ZFIN:ZDB-GENE-031010-34
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: sb:cb947
Summary: Acts upstream of or within gastrulation. Predicted to be part of intraciliary transport particle A. Is expressed in Kupffer's vesicle; forerunner cell group; neural tube; and pronephric duct. Human ortholog(s) of this gene implicated in asphyxiating thoracic dystrophy 4 and nephronophthisis 12. Orthologous to human TTC21B (tetratricopeptide repeat domain 21B). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 9

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	9	NC_007120.7 (49808483..49860756, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	9	NC_007120.6 (50111092..50163365, complement)

Chromosome 9 - NC_007120.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
acts_upstream_of_or_within gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intraciliary retrograde transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to cilium	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of intraciliary transport particle A	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: tetratricopeptide repeat protein 21B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001128258.1 → NP_001121730.1 tetratricopeptide repeat protein 21B

Status: PROVISIONAL

Source sequence(s)

AL929294

UniProtKB/TrEMBL

A0A8M1NHS0, B0R0W1

Related

ENSDARP00000044269.8, ENSDART00000044270.11

Conserved Domains (4) summary

TIGR02917
Location:16 → 822

PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein

sd00006
Location:730 → 755

TPR; TPR repeat [structural motif]

pfam13414
Location:1205 → 1266

TPR_11; TPR repeat

pfam13432
Location:927 → 990

TPR_16; Tetratricopeptide repeat