Nt5dc2 5'-nucleotidase domain containing 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nt5dc2provided by RGD
Official Full Name: 5'-nucleotidase domain containing 2provided by RGD
Primary source: RGD:1305524
See related: EnsemblRapid:ENSRNOG00000018358 AllianceGenome:RGD:1305524
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1305524
Summary: Predicted to enable 5'-nucleotidase activity. Predicted to be located in mitochondrion. Orthologous to human NT5DC2 (5'-nucleotidase domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 73.3), Lung (RPKM 45.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16p16

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (6328925..6336978)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (6322485..6330538)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (7212488..7220541)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results indicate that NT5DC2 inhibited the synthesis of dopamine by decreasing the enzymatic activity of tyrosine hydroxylase.
Title: Identification by nano-LC-MS/MS of NT5DC2 as a protein binding to tyrosine hydroxylase: Down-regulation of NT5DC2 by siRNA increases catecholamine synthesis in PC12D cells.

Submit: New GeneRIF Correction

General gene information

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Markers

Nt5dc2 (e-PCR), detects polymorphism
- UniSTS:498787

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 5'-nucleotidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of catecholamine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of dopamine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of oxidoreductase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of peptidyl-serine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: 5'-nucleotidase domain-containing protein 2

Names: eye irido-corneal angle unknown protein

NP_001009271.1

EC 3.1.3.5

XP_008769208.3

EC 3.1.3.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.