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    Htr7 5-hydroxytryptamine receptor 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 65032, updated on 9-Dec-2024

    Summary

    Symbol
    Htr7provided by RGD
    Full Name
    5-hydroxytryptamine receptor 7provided by RGD
    Primary source
    RGD:71034
    See related
    EnsemblRapid:ENSRNOG00000018827 AllianceGenome:RGD:71034
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    5Ht7
    Summary
    Enables G protein-coupled serotonin receptor activity and neurotransmitter receptor activity. Involved in several processes, including adenylate cyclase-activating serotonin receptor signaling pathway; detection of mechanical stimulus involved in sensory perception of pain; and modulation of chemical synaptic transmission. Located in several cellular components, including axon terminus; neuronal cell body; and synaptic vesicle. Is active in postsynaptic membrane and presynaptic membrane. Used to study amnestic disorder; anxiety disorder; childhood absence epilepsy; cognitive disorder; and migraine. Biomarker of irritable bowel syndrome. Human ortholog(s) of this gene implicated in alcohol use disorder. Orthologous to human HTR7 (5-hydroxytryptamine receptor 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 28.7), Spleen (RPKM 13.2) and 8 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Htr7 in Genome Data Viewer
    Location:
    1q53
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (243049064..243173636, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (233636442..233761063, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (254547964..254671811, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120100024 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene uncharacterized LOC134485228 Neighboring gene uncharacterized LOC134485226 Neighboring gene ribonuclease P/MRP subunit p30

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled serotonin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables G protein-coupled serotonin receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables G protein-coupled serotonin receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables G protein-coupled serotonin receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables neurotransmitter receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables neurotransmitter receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables serotonin receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables serotonin receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in G protein-coupled serotonin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in adenylate cyclase-activating serotonin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in adenylate cyclase-activating serotonin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in adenylate cyclase-activating serotonin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in behavioral response to pain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chemical synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in circadian rhythm IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in detection of mechanical stimulus involved in sensory perception of pain IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in dopaminergic neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in long-term synaptic potentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of serotonin secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of neuron projection development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in presynaptic modulation of chemical synaptic transmission EXP
    Inferred from Experiment
    more info
    PubMed 
    involved_in presynaptic modulation of chemical synaptic transmission IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of vein smooth muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to corticosterone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to electrical stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in serotonin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in smooth muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in urinary bladder smooth muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in vasoconstriction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in axon terminus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    5-hydroxytryptamine receptor 7
    Names
    5-HT-7
    5-HT-X
    5-HT7
    5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
    GPRFO
    high affinity serotonin receptor (5HT7)
    serotonin receptor 7

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022938.2NP_075227.1  5-hydroxytryptamine receptor 7

      See identical proteins and their annotated locations for NP_075227.1

      Status: PROVISIONAL

      Source sequence(s)
      U68489
      UniProtKB/TrEMBL
      A0A0G2K0E3, A6I144
      Related
      ENSRNOP00000025450.6, ENSRNOT00000025450.9
      Conserved Domains (2) summary
      pfam00001
      Location:101387
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:101222
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      243049064..243173636 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006231307.4XP_006231369.1  5-hydroxytryptamine receptor 7 isoform X1

      See identical proteins and their annotated locations for XP_006231369.1

      UniProtKB/Swiss-Prot
      P32305, P97936
      UniProtKB/TrEMBL
      A0A8L2R8K1
      Related
      ENSRNOP00000082600.1, ENSRNOT00000111885.2
      Conserved Domains (2) summary
      pfam00001
      Location:101387
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:101222
      7tm_4; Olfactory receptor
    2. XM_039089833.2XP_038945761.1  5-hydroxytryptamine receptor 7 isoform X2

      Conserved Domains (2) summary
      cd14964
      Location:121
      7tm_GPCRs; TM helix 4 [structural motif]
      cl28897
      Location:1197
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    3. XM_039089840.2XP_038945768.1  5-hydroxytryptamine receptor 7 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K5P0, P97842
      Conserved Domains (1) summary
      cd15329
      Location:100398
      7tmA_5-HT7; serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors