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    Dcx doublecortin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 84394, updated on 3-Dec-2024

    Summary

    Official Symbol
    Dcxprovided by RGD
    Official Full Name
    doublecortinprovided by RGD
    Primary source
    RGD:620670
    See related
    EnsemblRapid:ENSRNOG00000047712 AllianceGenome:RGD:620670
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    This gene encodes a member of the doublecortin family. The protein encoded by this gene contains two doublecortin domains, which bind microtubules and regulate microtubule polymerization. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. Studies in knockout mice lacking this gene suggest that this gene has a cortical role in nuclear translocation and positioning of the mitotic spindle in radial glial mitotic division. This gene is essential for neuronal migration, differentiation, and plasticity, is required for hippocampal development and also plays a role in dendrites development.[provided by RefSeq, Sep 2010]
    Expression
    Biased expression in Brain (RPKM 85.5), Testes (RPKM 19.7) and 2 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Dcx in Genome Data Viewer
    Location:
    Xq33-q34
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (112227455..112370291, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (107430767..107573612, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (115098675..115175515, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene p21 (RAC1) activated kinase 3 Neighboring gene calpain 6 Neighboring gene cyclin-dependent kinase 11B like 1 Neighboring gene high mobility group box 1 like 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables microtubule binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in axon extension IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within axon extension ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in axoneme assembly IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within brain development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in central nervous system projection neuron axonogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within central nervous system projection neuron axonogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in dendrite morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within dendrite morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in hippocampus development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within hippocampus development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in layer formation in cerebral cortex IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within layer formation in cerebral cortex ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neuron migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of collateral sprouting IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in pyramidal neuron development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within pyramidal neuron development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of postsynapse assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of postsynapse assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to electrical stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in retina development in camera-type eye IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in spinal cord development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in growth cone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuron projection ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in presynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    neuronal migration protein doublecortin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053379.3NP_445831.3  neuronal migration protein doublecortin

      See identical proteins and their annotated locations for NP_445831.3

      Status: REVIEWED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/Swiss-Prot
      Q9ESI7
      UniProtKB/TrEMBL
      A6KG86, G3V997
      Related
      ENSRNOP00000065381.1, ENSRNOT00000074322.3
      Conserved Domains (3) summary
      cd16112
      Location:51139
      DCX1_DCX; Dublecortin-like domain 1 found in neuronal migration protein doublecortin (DCX)
      cd17069
      Location:176259
      DCX2; Dublecortin-like domain 2
      cl40450
      Location:284343
      KLF8_12_N; N-terminal domain of Kruppel-like factor (KLF) 8, KLF12, and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      112227455..112370291 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039100106.2XP_038956034.1  neuronal migration protein doublecortin isoform X1

      UniProtKB/Swiss-Prot
      Q9ESI7
      Conserved Domains (3) summary
      cd16112
      Location:51139
      DCX1_DCX; Dublecortin-like domain 1 found in neuronal migration protein doublecortin (DCX)
      cd17069
      Location:176259
      DCX2; Dublecortin-like domain 2
      cl40450
      Location:284343
      KLF8_12_N; N-terminal domain of Kruppel-like factor (KLF) 8, KLF12, and similar proteins
    2. XM_006257386.5XP_006257448.1  neuronal migration protein doublecortin isoform X2

      UniProtKB/Swiss-Prot
      Q9ESI7
      Conserved Domains (3) summary
      cd16112
      Location:51139
      DCX1_DCX; Dublecortin-like domain 1 found in neuronal migration protein doublecortin (DCX)
      cd17069
      Location:176259
      DCX2; Dublecortin-like domain 2
      cl40450
      Location:284338
      KLF8_12_N; N-terminal domain of Kruppel-like factor (KLF) 8, KLF12, and similar proteins
    3. XM_063280337.1XP_063136407.1  neuronal migration protein doublecortin isoform X3

      UniProtKB/Swiss-Prot
      Q9ESI7
    4. XM_063280339.1XP_063136409.1  neuronal migration protein doublecortin isoform X5

      UniProtKB/TrEMBL
      A0A8I6GLD6, A6KG88
    5. XM_063280338.1XP_063136408.1  neuronal migration protein doublecortin isoform X4

      UniProtKB/TrEMBL
      A6KG88
    6. XM_006257385.5XP_006257447.1  neuronal migration protein doublecortin isoform X1

      See identical proteins and their annotated locations for XP_006257447.1

      UniProtKB/Swiss-Prot
      Q9ESI7
      Conserved Domains (3) summary
      cd16112
      Location:51139
      DCX1_DCX; Dublecortin-like domain 1 found in neuronal migration protein doublecortin (DCX)
      cd17069
      Location:176259
      DCX2; Dublecortin-like domain 2
      cl40450
      Location:284343
      KLF8_12_N; N-terminal domain of Kruppel-like factor (KLF) 8, KLF12, and similar proteins
    7. XM_006257382.4XP_006257444.1  neuronal migration protein doublecortin isoform X1

      See identical proteins and their annotated locations for XP_006257444.1

      UniProtKB/Swiss-Prot
      Q9ESI7
      Conserved Domains (3) summary
      cd16112
      Location:51139
      DCX1_DCX; Dublecortin-like domain 1 found in neuronal migration protein doublecortin (DCX)
      cd17069
      Location:176259
      DCX2; Dublecortin-like domain 2
      cl40450
      Location:284343
      KLF8_12_N; N-terminal domain of Kruppel-like factor (KLF) 8, KLF12, and similar proteins
    8. XM_017602167.3XP_017457656.1  neuronal migration protein doublecortin isoform X1

      UniProtKB/Swiss-Prot
      Q9ESI7
      Conserved Domains (3) summary
      cd16112
      Location:51139
      DCX1_DCX; Dublecortin-like domain 1 found in neuronal migration protein doublecortin (DCX)
      cd17069
      Location:176259
      DCX2; Dublecortin-like domain 2
      cl40450
      Location:284343
      KLF8_12_N; N-terminal domain of Kruppel-like factor (KLF) 8, KLF12, and similar proteins