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    Chrnb1 cholinergic receptor nicotinic beta 1 subunit [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24261, updated on 9-Dec-2024

    Summary

    Official Symbol
    Chrnb1provided by RGD
    Official Full Name
    cholinergic receptor nicotinic beta 1 subunitprovided by RGD
    Primary source
    RGD:2349
    See related
    EnsemblRapid:ENSRNOG00000014698 AllianceGenome:RGD:2349
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Acrb; nAChR; RNACRB1
    Summary
    Enables acetylcholine-gated monoatomic cation-selective channel activity. Involved in monoatomic cation transport and skeletal muscle contraction. Part of acetylcholine-gated channel complex. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 2A and congenital myasthenic syndrome 2C. Orthologous to human CHRNB1 (cholinergic receptor nicotinic beta 1 subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 126.3), Kidney (RPKM 20.2) and 2 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Chrnb1 in Genome Data Viewer
    Location:
    10q24
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (54999943..55015137, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (54501096..54516418, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (56390671..56403255, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene RNA polymerase II subunit A Neighboring gene solute carrier family 35, member G3 Neighboring gene zinc finger and BTB domain containing 4 Neighboring gene fibroblast growth factor 11 Neighboring gene transmembrane protein 102

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables acetylcholine binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables acetylcholine binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables acetylcholine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables acetylcholine receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to acetylcholine receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables acetylcholine-gated monoatomic cation-selective channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables acetylcholine-gated monoatomic cation-selective channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to acetylcholine-gated monoatomic cation-selective channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables acetylcholine-gated monoatomic cation-selective channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables excitatory extracellular ligand-gated monoatomic ion channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ligand-gated monoatomic ion channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in acetylcholine receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in behavioral response to nicotine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in behavioral response to nicotine ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in excitatory postsynaptic potential IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in membrane depolarization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in monoatomic cation transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in monoatomic cation transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in monoatomic cation transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in monoatomic ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in muscle cell development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in muscle cell development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nervous system process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuromuscular synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuromuscular synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in postsynaptic membrane organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in postsynaptic membrane organization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in skeletal muscle contraction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in synaptic transmission, cholinergic IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in synaptic transmission, cholinergic ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of acetylcholine-gated channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of acetylcholine-gated channel complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of acetylcholine-gated channel complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of acetylcholine-gated channel complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuromuscular junction IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in neuromuscular junction ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in postsynaptic specialization membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in postsynaptic specialization membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    acetylcholine receptor subunit beta
    Names
    Acetylcholine receptor beta
    cholinergic receptor nicotinic beta polypeptide 1
    cholinergic receptor, nicotinic beta 1
    cholinergic receptor, nicotinic, beta 1 (muscle)
    cholinergic receptor, nicotinic, beta polypeptide 1 (muscle)
    n acetylcholine receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395118.3NP_001382047.1  acetylcholine receptor subunit beta isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I6AYT8, A0A8L2UJI2
      Conserved Domains (2) summary
      cd19024
      Location:27248
      LGIC_ECD_nAChR_B1; extracellular domain of nicotinic acetylcholine receptor subunit beta 1 (CHRNB1)
      pfam02932
      Location:255490
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
    2. NM_001429878.1NP_001416807.1  acetylcholine receptor subunit beta isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
    3. NM_001429879.1NP_001416808.1  acetylcholine receptor subunit beta isoform 4 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
    4. NM_012528.4NP_036660.1  acetylcholine receptor subunit beta isoform 2 precursor

      See identical proteins and their annotated locations for NP_036660.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      P25109
      UniProtKB/TrEMBL
      A0A8I6AYT8, A6HFT8
      Related
      ENSRNOP00000089285.2, ENSRNOT00000110050.2
      Conserved Domains (3) summary
      TIGR00860
      Location:24488
      LIC; Cation transporter family protein
      pfam02931
      Location:27245
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:252487
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      54999943..55015137 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039085172.2XP_038941100.1  acetylcholine receptor subunit beta isoform X1

      UniProtKB/TrEMBL
      A0A8I6AYT8, A0A8L2UJI2
      Conserved Domains (2) summary
      cd19024
      Location:27248
      LGIC_ECD_nAChR_B1; extracellular domain of nicotinic acetylcholine receptor subunit beta 1 (CHRNB1)
      pfam02932
      Location:255490
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
    2. XM_039085174.2XP_038941102.1  acetylcholine receptor subunit beta isoform X3

      Conserved Domains (3) summary
      cd19024
      Location:27245
      LGIC_ECD_nAChR_B1; extracellular domain of nicotinic acetylcholine receptor subunit beta 1 (CHRNB1)
      cd03559
      Location:246270
      LGIC_TM; TM1 helix [structural motif]
      cl38911
      Location:246273
      LGIC_TM; transmembrane domain of Cys-loop neurotransmitter-gated ion channels
    3. XM_039085173.2XP_038941101.1  acetylcholine receptor subunit beta isoform X2

      Conserved Domains (3) summary
      cd19024
      Location:27248
      LGIC_ECD_nAChR_B1; extracellular domain of nicotinic acetylcholine receptor subunit beta 1 (CHRNB1)
      cd03559
      Location:249273
      LGIC_TM; TM1 helix [structural motif]
      cl38911
      Location:249276
      LGIC_TM; transmembrane domain of Cys-loop neurotransmitter-gated ion channels