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    Ssh2 slingshot protein phosphatase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303342, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ssh2provided by RGD
    Official Full Name
    slingshot protein phosphatase 2provided by RGD
    Primary source
    RGD:1309389
    See related
    EnsemblRapid:ENSRNOG00000014285 AllianceGenome:RGD:1309389
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable actin binding activity and phosphoprotein phosphatase activity. Involved in positive regulation of cell migration. Predicted to be active in cytoplasm. Orthologous to human SSH2 (slingshot protein phosphatase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 163.7), Spleen (RPKM 156.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ssh2 in Genome Data Viewer
    Location:
    10q24
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (62555388..62807457)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (62057400..62309328)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (62702286..62954907, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene nuclear speckle splicing regulatory protein 1 Neighboring gene microRNA 423 Neighboring gene EF-hand calcium binding domain 5 Neighboring gene uncharacterized LOC134480826 Neighboring gene uncharacterized LOC120095265 Neighboring gene ankyrin repeat domain 13B Neighboring gene coronin 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Suppression of the invasive capacity of rat ascites hepatoma cells by knockdown of Slingshot or LIM kinase. Horita Y, et al. J Biol Chem, 2008 Mar 7. PMID 18171679
    2. Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin. Niwa R, et al. Cell, 2002 Jan 25. PMID 11832213
    3. Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. Böhm D, et al. Oncol Rep, 2012 Aug. PMID 22664934, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. both LIMK1-mediated phosphorylation and SSH1/SSH2-mediated dephosphorylation of cofilin/ADF are critical for the migration and invasion of tumor cells
      Title: Suppression of the invasive capacity of rat ascites hepatoma cells by knockdown of Slingshot or LIM kinase.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables MAP kinase serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calmodulin-dependent protein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS140 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphoprotein phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of actin filament polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein phosphatase Slingshot homolog 2
    Names
    slingshot homolog 2
    NP_001100494.1
    XP_006246967.1
    XP_038941949.1
    XP_038941950.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107024.1 → NP_001100494.1  protein phosphatase Slingshot homolog 2

      See identical proteins and their annotated locations for NP_001100494.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473948
      UniProtKB/TrEMBL
      A0A8I6APG2, A6HGX4, F1M4Q5
      Related
      ENSRNOP00000019410.6, ENSRNOT00000019410.8
      Conserved Domains (3) summary
      cd11652
      Location:10 → 243
      SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
      cd00127
      Location:315 → 450
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
      pfam08766
      Location:258 → 309
      DEK_C; DEK C terminal domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      62555388..62807457
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006246905.5 → XP_006246967.1  protein phosphatase Slingshot homolog 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6APG2, A0A8I6ATT8
      Related
      ENSRNOP00000106220.1, ENSRNOT00000172940.1
      Conserved Domains (3) summary
      cd11652
      Location:3 → 236
      SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
      cd00127
      Location:308 → 443
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
      pfam08766
      Location:251 → 302
      DEK_C; DEK C terminal domain

    2. XM_039086021.2 → XP_038941949.1  protein phosphatase Slingshot homolog 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6APG2
      Related
      ENSRNOP00000101336.1, ENSRNOT00000158620.1
      Conserved Domains (3) summary
      cd11652
      Location:38 → 263
      SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
      cd14569
      Location:332 → 475
      DSP_slingshot_2; dual specificity phosphatase domain of slingshot homolog 2
      pfam08766
      Location:277 → 329
      DEK_C; DEK C terminal domain

    3. XM_039086022.1 → XP_038941950.1  protein phosphatase Slingshot homolog 2 isoform X3

      UniProtKB/TrEMBL
      A0A8I6APG2
      Related
      ENSRNOP00000091756.2, ENSRNOT00000100799.2
      Conserved Domains (3) summary
      cd11652
      Location:4 → 218
      SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
      cd14569
      Location:287 → 430
      DSP_slingshot_2; dual specificity phosphatase domain of slingshot homolog 2
      pfam08766
      Location:232 → 284
      DEK_C; DEK C terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version

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