Mgat3 beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mgat3provided by RGD
Official Full Name: beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferaseprovided by RGD
Primary source: RGD:3084
See related: EnsemblRapid:ENSRNOG00000017434 AllianceGenome:RGD:3084
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity. Predicted to be involved in N-acetylglucosamine metabolic process; protein localization; and regulation of cell migration. Predicted to act upstream of or within several processes, including negative regulation of lysosomal protein catabolic process; positive regulation of protein localization to early endosome; and protein N-linked glycosylation. Predicted to be located in Golgi membrane and lysosome. Orthologous to human MGAT3 (beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 173.8), Kidney (RPKM 154.6) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q34

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (113614011..113640201)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (111708353..111761825)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (121394541..121436935)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GnT-III transfection has the potential to be an effective approach in humanizing the N-glycosylation of lepidopteran insect cells.
Title: N-Glycosylation engineering of lepidopteran insect cells by the introduction of the beta1,4-N-acetylglucosaminyltransferase III gene.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity	ISO Inferred from Sequence Orthology more info
enables beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables glycosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycosyltransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in N-acetylglucosamine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within N-acetylglucosamine metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within amyloid-beta metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within amyloid-beta metabolic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cellular response to oxidative stress	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to oxidative stress	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cognition	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cognition	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of lysosomal protein catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of lysosomal protein catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of lysosomal protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of protein localization to early endosome	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of protein localization to early endosome	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein N-linked glycosylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein N-linked glycosylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization	ISO Inferred from Sequence Orthology more info
involved_in protein localization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of protein localization to early endosome	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell migration	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in lysosome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase

Names: GNT-III; N-acetylglucosaminyltransferase III; N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III; glcNAc-T III; mannoside acetyl glucosaminyltransferase 3; mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase

NP_062112.2

EC 2.4.1.144

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019239.2 → NP_062112.2 beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase

See identical proteins and their annotated locations for NP_062112.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/Swiss-Prot

Q02527

UniProtKB/TrEMBL

A6HSW0

Related

ENSRNOP00000082287.1, ENSRNOT00000109650.2

Conserved Domains (1) summary

pfam04724
Location:205 → 502

Glyco_transf_17; Glycosyltransferase family 17