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    CRCT1 cysteine rich C-terminal 1 [ Homo sapiens (human) ]

    Gene ID: 54544, updated on 27-Nov-2024

    Summary

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    Official Symbol
    CRCT1provided by HGNC
    Official Full Name
    cysteine rich C-terminal 1provided by HGNC
    Primary source
    HGNC:HGNC:29875
    See related
    Ensembl:ENSG00000169509 MIM:617426; AllianceGenome:HGNC:29875
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NICE1; NICE-1; C1orf42
    Expression
    Biased expression in skin (RPKM 17.3) and esophagus (RPKM 17.1) See more
    Orthologs
    mouse all
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    Genomic context

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    See CRCT1 in Genome Data Viewer
    Location:
    1q21.3
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (152514482..152516008)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (151651031..151652559)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (152486958..152488484)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene cornulin Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1731 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1732 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:152443806-152444710 Neighboring gene late cornified envelope 5A Neighboring gene late cornified envelope 3E Neighboring gene late cornified envelope 3D

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. CRCT1 regulated by microRNA-520 g inhibits proliferation and induces apoptosis in esophageal squamous cell cancer. Wu N, et al. Tumour Biol, 2016 Jun. PMID 26718216
    2. Identification of human epidermal differentiation complex (EDC)-encoded genes by subtractive hybridization of entire YACs to a gridded keratinocyte cDNA library. Marenholz I, et al. Genome Res, 2001 Mar. PMID 11230159, Free PMC Article
    3. Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. Torgerson DG, et al. Nat Genet, 2011 Jul 31. PMID 21804549, Free PMC Article
    4. Network-based prediction of protein interactions. Kovács IA, et al. Nat Commun, 2019 Mar 18. PMID 30886144, Free PMC Article
    5. DCAF8, a novel MuRF1 interaction partner, promotes muscle atrophy. Nowak M, et al. J Cell Sci, 2019 Sep 6. PMID 31391242

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CRCT1 functions as a tumor suppressor gene in ESCC and is regulated by miR-520 g, providing potential therapeutic targets for the treatment of ESCC
      Title: CRCT1 regulated by microRNA-520 g inhibits proliferation and induces apoptosis in esophageal squamous cell cancer.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.
    EBI GWAS Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cysteine-rich C-terminal protein 1
    Names
    protein NICE-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019060.3 → NP_061933.1  cysteine-rich C-terminal protein 1

      See identical proteins and their annotated locations for NP_061933.1

      Status: VALIDATED

      Source sequence(s)
      AJ243662, AL135842
      Consensus CDS
      CCDS1012.1
      UniProtKB/Swiss-Prot
      A4QN00, Q6IAD7, Q9UGL9
      Related
      ENSP00000357779.3, ENST00000368790.4

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      152514482..152516008
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011509656.3 → XP_011507958.1  cysteine-rich C-terminal protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011507958.1

      UniProtKB/Swiss-Prot
      A4QN00, Q6IAD7, Q9UGL9

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      151651031..151652559
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054337138.1 → XP_054193113.1  cysteine-rich C-terminal protein 1 isoform X1

      UniProtKB/Swiss-Prot
      A4QN00, Q6IAD7, Q9UGL9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UGL9.1 GenPept UniProtKB/Swiss-Prot:Q9UGL9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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