HSF5 heat shock transcription factor 5 [Homo sapiens (human)] - Gene

Summary

Official Symbol: HSF5provided by HGNC
Official Full Name: heat shock transcription factor 5provided by HGNC
Primary source: HGNC:HGNC:26862
See related: Ensembl:ENSG00000176160 MIM:620843; AllianceGenome:HGNC:26862
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HSF 5; HSTF 5
Summary: Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in XY body. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward testis (RPKM 33.9) See more
Orthologs: mouse all
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Genomic context

Location:: 17q22

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (58420167..58488408, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (59288027..59356284, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (56497528..56565769, complement)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Heat shock factor 5 correlated with immune infiltration serves as a prognostic biomarker in lung adenocarcinoma.
Title: Heat shock factor 5 correlated with immune infiltration serves as a prognostic biomarker in lung adenocarcinoma.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of vitamin D levels in children: replication in the Western Australian Pregnancy Cohort (Raine) study. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH98431 (e-PCR)
- UniSTS:86533

PMC310730P1 (e-PCR)
- UniSTS:272659

G42608 (e-PCR)
- UniSTS:94509

D17S1363E (e-PCR)
- UniSTS:27972

D17S1780 (e-PCR)
- UniSTS:154192

G06215 (e-PCR)
- UniSTS:42848

AA596759 (e-PCR), detects polymorphism
- UniSTS:143030

STS-H68355 (e-PCR)
- UniSTS:43997

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription repressor activity	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in male meiotic nuclear division	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in XY body	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: heat shock factor protein 5

Names: heat shock transcription factor family member 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001080439.3 → NP_001073908.2 heat shock factor protein 5

See identical proteins and their annotated locations for NP_001073908.2

Status: VALIDATED

Source sequence(s)

AC005666, BC033017, BI459434

Consensus CDS

CCDS32690.1

UniProtKB/Swiss-Prot

Q08EH7, Q4G112, Q8N7V2

Related

ENSP00000313243.3, ENST00000323777.8

Conserved Domains (1) summary

pfam00447
Location:20 → 129

HSF_DNA-bind; HSF-type DNA-binding

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000017.11 Reference GRCh38.p14 Primary Assembly

Range

58420167..58488408 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011524283.2 → XP_011522585.1 heat shock factor protein 5 isoform X1

Conserved Domains (1) summary

pfam00447
Location:20 → 129

HSF_DNA-bind; HSF-type DNA-binding